Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium

H.D. Bailey, L. Fritschi, C. Métayer, C. Infante-Rivard, C. Magnani, E.T.H. Petridou, E.A. Roman, L.G. Spector, P. Kaatsch, J. Clavel, Elizabeth Milne, J.D. Dockerty, D.C. Glass, T.J. Lightfoot, L. Miligi, J. Rudant, M. Baka, R. Rondelli, A. Amigou, J.M. Simpson & 3 others A.Y. Kang, M.A. Moschovi, J. Schüz

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose: It has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring.

Methods: We obtained individual level data from 13 case–control studies participating in the Childhood Leukemia International Consortium. Occupational data were harmonized to a compatible format. Meta-analyses of study-specific odds ratios (ORs) were undertaken, as well as pooled analyses of individual data using unconditional logistic regression.

Results: Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukemia (ALL) was 0.93 [95 % confidence interval (CI) 0.76, 1.14]. Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 (95 % CI 0.39, 1.68) for exposure during pregnancy. For acute myeloid leukemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 (95 % CI 0.65, 1.41) and 1.31 (95 % CI 0.38, 4.47), respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers. Heterogeneity among the individual studies ranged from low to modest.

Conclusions: Null findings for paternal exposure for both ALL and AML are consistent with previous reports. Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed. Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed.
Original languageEnglish
Pages (from-to)1351-1367
JournalCancer Causes & Control
Volume25
Issue number10
Early online date5 Aug 2014
DOIs
Publication statusPublished - Oct 2014

Fingerprint

Paternal Exposure
Paint
Occupational Exposure
Leukemia
Odds Ratio
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Confidence Intervals
Maternal Exposure
Mothers
Acute Myeloid Leukemia
Fathers
Pregnancy
Sample Size
Meta-Analysis
Logistic Models

Cite this

Bailey, H.D. ; Fritschi, L. ; Métayer, C. ; Infante-Rivard, C. ; Magnani, C. ; Petridou, E.T.H. ; Roman, E.A. ; Spector, L.G. ; Kaatsch, P. ; Clavel, J. ; Milne, Elizabeth ; Dockerty, J.D. ; Glass, D.C. ; Lightfoot, T.J. ; Miligi, L. ; Rudant, J. ; Baka, M. ; Rondelli, R. ; Amigou, A. ; Simpson, J.M. ; Kang, A.Y. ; Moschovi, M.A. ; Schüz, J. / Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium. In: Cancer Causes & Control. 2014 ; Vol. 25, No. 10. pp. 1351-1367.
@article{e071d1e9880e4f759c6604a3c50e7237,
title = "Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium",
abstract = "Purpose: It has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring. Methods: We obtained individual level data from 13 case–control studies participating in the Childhood Leukemia International Consortium. Occupational data were harmonized to a compatible format. Meta-analyses of study-specific odds ratios (ORs) were undertaken, as well as pooled analyses of individual data using unconditional logistic regression. Results: Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukemia (ALL) was 0.93 [95 {\%} confidence interval (CI) 0.76, 1.14]. Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 (95 {\%} CI 0.39, 1.68) for exposure during pregnancy. For acute myeloid leukemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 (95 {\%} CI 0.65, 1.41) and 1.31 (95 {\%} CI 0.38, 4.47), respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers. Heterogeneity among the individual studies ranged from low to modest. Conclusions: Null findings for paternal exposure for both ALL and AML are consistent with previous reports. Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed. Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed.",
author = "H.D. Bailey and L. Fritschi and C. M{\'e}tayer and C. Infante-Rivard and C. Magnani and E.T.H. Petridou and E.A. Roman and L.G. Spector and P. Kaatsch and J. Clavel and Elizabeth Milne and J.D. Dockerty and D.C. Glass and T.J. Lightfoot and L. Miligi and J. Rudant and M. Baka and R. Rondelli and A. Amigou and J.M. Simpson and A.Y. Kang and M.A. Moschovi and J. Sch{\"u}z",
year = "2014",
month = "10",
doi = "10.1007/s10552-014-0441-z",
language = "English",
volume = "25",
pages = "1351--1367",
journal = "Cancer Causes & Control",
issn = "0957-5243",
publisher = "Springer",
number = "10",

}

Bailey, HD, Fritschi, L, Métayer, C, Infante-Rivard, C, Magnani, C, Petridou, ETH, Roman, EA, Spector, LG, Kaatsch, P, Clavel, J, Milne, E, Dockerty, JD, Glass, DC, Lightfoot, TJ, Miligi, L, Rudant, J, Baka, M, Rondelli, R, Amigou, A, Simpson, JM, Kang, AY, Moschovi, MA & Schüz, J 2014, 'Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium' Cancer Causes & Control, vol. 25, no. 10, pp. 1351-1367. https://doi.org/10.1007/s10552-014-0441-z

Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium. / Bailey, H.D.; Fritschi, L.; Métayer, C.; Infante-Rivard, C.; Magnani, C.; Petridou, E.T.H.; Roman, E.A.; Spector, L.G.; Kaatsch, P.; Clavel, J.; Milne, Elizabeth; Dockerty, J.D.; Glass, D.C.; Lightfoot, T.J.; Miligi, L.; Rudant, J.; Baka, M.; Rondelli, R.; Amigou, A.; Simpson, J.M.; Kang, A.Y.; Moschovi, M.A.; Schüz, J.

In: Cancer Causes & Control, Vol. 25, No. 10, 10.2014, p. 1351-1367.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium

AU - Bailey, H.D.

AU - Fritschi, L.

AU - Métayer, C.

AU - Infante-Rivard, C.

AU - Magnani, C.

AU - Petridou, E.T.H.

AU - Roman, E.A.

AU - Spector, L.G.

AU - Kaatsch, P.

AU - Clavel, J.

AU - Milne, Elizabeth

AU - Dockerty, J.D.

AU - Glass, D.C.

AU - Lightfoot, T.J.

AU - Miligi, L.

AU - Rudant, J.

AU - Baka, M.

AU - Rondelli, R.

AU - Amigou, A.

AU - Simpson, J.M.

AU - Kang, A.Y.

AU - Moschovi, M.A.

AU - Schüz, J.

PY - 2014/10

Y1 - 2014/10

N2 - Purpose: It has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring. Methods: We obtained individual level data from 13 case–control studies participating in the Childhood Leukemia International Consortium. Occupational data were harmonized to a compatible format. Meta-analyses of study-specific odds ratios (ORs) were undertaken, as well as pooled analyses of individual data using unconditional logistic regression. Results: Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukemia (ALL) was 0.93 [95 % confidence interval (CI) 0.76, 1.14]. Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 (95 % CI 0.39, 1.68) for exposure during pregnancy. For acute myeloid leukemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 (95 % CI 0.65, 1.41) and 1.31 (95 % CI 0.38, 4.47), respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers. Heterogeneity among the individual studies ranged from low to modest. Conclusions: Null findings for paternal exposure for both ALL and AML are consistent with previous reports. Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed. Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed.

AB - Purpose: It has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring. Methods: We obtained individual level data from 13 case–control studies participating in the Childhood Leukemia International Consortium. Occupational data were harmonized to a compatible format. Meta-analyses of study-specific odds ratios (ORs) were undertaken, as well as pooled analyses of individual data using unconditional logistic regression. Results: Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukemia (ALL) was 0.93 [95 % confidence interval (CI) 0.76, 1.14]. Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 (95 % CI 0.39, 1.68) for exposure during pregnancy. For acute myeloid leukemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 (95 % CI 0.65, 1.41) and 1.31 (95 % CI 0.38, 4.47), respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers. Heterogeneity among the individual studies ranged from low to modest. Conclusions: Null findings for paternal exposure for both ALL and AML are consistent with previous reports. Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed. Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed.

U2 - 10.1007/s10552-014-0441-z

DO - 10.1007/s10552-014-0441-z

M3 - Article

VL - 25

SP - 1351

EP - 1367

JO - Cancer Causes & Control

JF - Cancer Causes & Control

SN - 0957-5243

IS - 10

ER -