Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses

H. Song, J. Qi, Joel Haywood, Y. Shi, G.F. Gao

Research output: Contribution to journalArticlepeer-review

167 Citations (Scopus)

Abstract

The association of Zika virus (ZIKV) infections with microcephaly has resulted in an ongoing public-health emergency. Here we report the crystal structure of a C-terminal fragment of ZIKV nonstructural protein 1 (NS1), a major host-interaction molecule that functions in flaviviral replication, pathogenesis and immune evasion. Comparison with West Nile and dengue virus NS1 structures reveals conserved features but diverse electrostatic characteristics at host-interaction interfaces, thus possibly implying different modes of flavivirus pathogenesis.
Original languageEnglish
Pages (from-to)456-458
Number of pages3
JournalNature Structural and Molecular Biology
Volume23
Issue number5
DOIs
Publication statusPublished - 1 May 2016

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