The association of Zika virus (ZIKV) infections with microcephaly has resulted in an ongoing public-health emergency. Here we report the crystal structure of a C-terminal fragment of ZIKV nonstructural protein 1 (NS1), a major host-interaction molecule that functions in flaviviral replication, pathogenesis and immune evasion. Comparison with West Nile and dengue virus NS1 structures reveals conserved features but diverse electrostatic characteristics at host-interaction interfaces, thus possibly implying different modes of flavivirus pathogenesis.
Song, H., Qi, J., Haywood, J., Shi, Y., & Gao, G. F. (2016). Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses. Nature Structural and Molecular Biology, 23(5), 456-458. https://doi.org/10.1038/nsmb.3213