ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

Arpita Poddar; Suneela Pyreddy; Francesco Carraro; Sudip Dhakal; Andrea Rassell; Matthew R. Field; T. Srinivasa Reddy; Paolo Falcaro; Cara M. Doherty; Ravi Shukla

doi:10.1039/d0cc06241c

ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

Arpita Poddar, Suneela Pyreddy, Francesco Carraro, Sudip Dhakal, Andrea Rassell, Matthew R. Field, T. Srinivasa Reddy, Paolo Falcaro, Cara M. Doherty, Ravi Shukla

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.

Original language	English
Pages (from-to)	15406-15409
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	98
DOIs	https://doi.org/10.1039/d0cc06241c
Publication status	Published - 21 Dec 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/d0cc06241c

Cite this

@article{c1cb50d2b4684940be3c73667bc48aeb,

title = "ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer",

abstract = "Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.",

author = "Arpita Poddar and Suneela Pyreddy and Francesco Carraro and Sudip Dhakal and Andrea Rassell and Field, {Matthew R.} and Reddy, {T. Srinivasa} and Paolo Falcaro and Doherty, {Cara M.} and Ravi Shukla",

year = "2020",

month = dec,

day = "21",

doi = "10.1039/d0cc06241c",

language = "English",

volume = "56",

pages = "15406--15409",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "ROYAL SOC CHEMISTRY",

number = "98",

}

TY - JOUR

T1 - ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

AU - Poddar, Arpita

AU - Pyreddy, Suneela

AU - Carraro, Francesco

AU - Dhakal, Sudip

AU - Rassell, Andrea

AU - Field, Matthew R.

AU - Reddy, T. Srinivasa

AU - Falcaro, Paolo

AU - Doherty, Cara M.

AU - Shukla, Ravi

PY - 2020/12/21

Y1 - 2020/12/21

N2 - Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.

AB - Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.

UR - http://www.scopus.com/inward/record.url?scp=85098471731&partnerID=8YFLogxK

U2 - 10.1039/d0cc06241c

DO - 10.1039/d0cc06241c

M3 - Article

C2 - 33196071

AN - SCOPUS:85098471731

SN - 1359-7345

VL - 56

SP - 15406

EP - 15409

JO - Chemical Communications

JF - Chemical Communications

IS - 98

ER -

ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this