ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

Arpita Poddar, Suneela Pyreddy, Francesco Carraro, Sudip Dhakal, Andrea Rassell, Matthew R. Field, T. Srinivasa Reddy, Paolo Falcaro, Cara M. Doherty, Ravi Shukla

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.

Original languageEnglish
Pages (from-to)15406-15409
Number of pages4
JournalChemical Communications
Volume56
Issue number98
DOIs
Publication statusPublished - 21 Dec 2020
Externally publishedYes

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