Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010

T. Vos, A.D. Flaxman, M. Naghavi, R. Lozano, C. Michaud, M. Ezzati, K. Shibuya, J.A. Salomon, S. Abdalla, V. Aboyans, J. Abraham, I. Ackerman, R. Aggarwal, S.Y. Ahn, M.K. Ali, M. Alvarado, H.R. Anderson, L.M. Anderson, K.G. Andrews, C. AtkinsonL.M. Baddour, A.N. Bahalim, S. Barker-Collo, L.H. Barrero, D.H. Bartels, M.-G. Basáñez, A. Baxter, M.L. Bell, E.J. Benjamin, D. Bennett, E. Bernabé, K. Bhalla, B. Bhandari, B. Bikbov, A.B. Abdulhak, G. Birbeck, J.A. Black, H. Blencowe, J.D. Blore, F. Blyth, I. Bolliger, A. Bonaventure, S. Boufous, R. Bourne, M. Boussinesq, T. Braithwaite, C. Brayne, L. Bridgett, S. Brooker, P. Brooks, T.S. Brugha, C. Bryan-Hancock, C. Bucello, R. Buchbinder, G. Buckle, C.M. Budke, M. Burch, P. Burney, R. Burstein, B. Calabria, B. Campbell, C.E. Canter, H. Carabin, Jonathan Carapetis, L. Carmona, C. Cella, F. Charlson, H. Chen, A.T.-A. Cheng, D. Chou, S.S. Chugh, L.E. Coffeng, S.D. Colan, S. Colquhoun, K.E. Colson, J. Condon, M.D. Connor, L.T. Cooper, M. Corriere, M. Cortinovis, K.C. De Vaccaro, W. Couser, B.C. Cowie, M.H. Criqui, M. Cross, K.C. Dabhadkar, M. Dahiya, N. Dahodwala, J. Damsere-Derry, G. Danaei, A. Davis, D. De Leo, L. Degenhardt, R. Dellavalle, A. Delossantos, J. Denenberg, S. Derrett, D.C. Des Jarlais, S.D. Dharmaratne, M. Dherani, C. Diaz-Torne, H. Dolk, E.R. Dorsey, T. Driscoll, H. Duber, B. Ebel, K. Edmond, A. Elbaz, S.E. Ali, H. Erskine, P.J. Erwin, P. Espindola, S.E. Ewoigbokhan, F. Farzadfar, V. Feigin, D.T. Felson, A. Ferrari, C.P. Ferri, E.M. Fèvre, M.M. Finucane, S. Flaxman, L. Flood, K. Foreman, M.H. Forouzanfar, F.G.R. Fowkes, R. Franklin, M. Fransen, M.K. Freeman, B.J. Gabbe, S.E. Gabriel, E. Gakidou, H.A. Ganatra, B. Garcia, F. Gaspari, R.F. Gillum, G. Gmel, D. Gonzalez-Medina, R. Gosselin, R. Grainger, B. Grant, J. Groeger, F. Guillemin, D. Gunnell, R. Gupta, J. Haagsma, H. Hagan, Y.A. Halasa, W. Hall, D. Haring, J.M. Haro, J.E. Harrison, R. Havmoeller, R.J. Hay, H. Higashi, C. Hill, B. Hoen, H. Hoffman, P.J. Hotez, D. Hoy, J.J. Huang, S.E. Ibeanusi, K.H. Jacobsen, S.L. James, D. Jarvis, R. Jasrasaria, S. Jayaraman, N. Johns, J.B. Jonas, G. Karthikeyan, N. Kassebaum, N. Kawakami, A. Keren, J.-P. Khoo, C.H. King, L.M. Knowlton, O. Kobusingye, A. Koranteng, R. Krishnamurthi, F. Laden, R. Lalloo, L.L. Laslett, T. Lathlean, J.L. Leasher, Y.Y. Lee, J. Leigh, D. Levinson, S.S. Lim, E. Limb, J.K. Lin, M. Lipnick, S.E. Lipshultz, W. Liu, M. Loane, S.L. Ohno, R. Lyons, J. Ma, J. Mabweijano, M.F. Macintyre, R. Malekzadeh, L. Mallinger, S. Manivannan, W. Marcenes, L. March, D.J. Margolis, G.B. Marks, R. Marks, A. Matsumori, R. Matzopoulos, B.M. Mayosi, J.H. Mcanulty, M.M. Mcdermott, N. Mcgill, J. Mcgrath, M.E. Medina-Mora, M. Meltzer, G.A. Mensah, T.R. Merriman, A.-C. Meyer, V. Miglioli, M. Miller, T.R. Miller, P.B. Mitchell, C. Mock, A.O. Mocumbi, T.E. Moffitt, A.A. Mokdad, L. Monasta, M. Montico, A. Moran, L. Morawska, R. Mori, M.E. Murdoch, M.K. Mwaniki, K. Naidoo, M.N. Nair, L. Naldi, K.M.V. Narayan, P.K. Nelson, R.G. Nelson, M.C. Nevitt, C.R. Newton, S. Nolte, P. Norman, Paul Norman, M. O'Donnell, S. O'Hanlon, C. Olives, S.B. Omer, K. Ortblad, R. Osborne, D. Ozgediz, A. Page, B. Pahari, J.D. Pandian, A.P. Rivero, S.B. Patten, N. Pearce, R.P. Padilla, F. Perez-Ruiz, N. Perico, K. Pesudovs, D. Phillips, M.R. Phillips, K. Pierce, S. Pion, G.V. Polanczyk, S. Polinder, C.A. Pope Iii, S. Popova, E. Porrini, F. Pourmalek, M. Prince, R.L. Pullan, K.D. Ramaiah, D. Ranganathan, H. Razavi, M. Regan, J.T. Rehm, D.B. Rein, G. Remuzzi, K. Richardson, F.P. Rivara, T. Roberts, C. Robinson, F.R. De Leòn, L. Ronfani, R. Room, L.C. Rosenfeld, L. Rushton, R.L. Sacco, S. Saha, U. Sampson, L. Sanchez-Riera, E. Sanman, D.C. Schwebel, J.G. Scott, M. Segui-Gomez, S. Shahraz, D.S. Shepard, H. Shin, R. Shivakoti, D. Singh, G.M. Singh, J.A. Singh, J. Singleton, D.A. Sleet, K. Sliwa, E. Smith, J.L. Smith, N.J.C. Stapelberg, A. Steer, T. Steiner, W.A. Stolk, L.J. Stovner, C. Sudfeld, S. Syed, G. Tamburlini, M. Tavakkoli, H.R. Taylor, J.A. Taylor, W.J. Taylor, B. Thomas, W.M. Thomson, G.D. Thurston, I.M. Tleyjeh, M. Tonelli, J.A. Towbin, T. Truelsen, M.K. Tsilimbaris, C. Ubeda, E.A. Undurraga, M.J. Van Der Werf, J. Van Os, M.S. Vavilala, N. Venketasubramanian, M. Wang, W. Wang, K. Watt, D.J. Weatherall, M.A. Weinstock, R. Weintraub, M.G. Weisskopf, M.M. Weissman, R.A. White, H. Whiteford, N. Wiebe, S.T. Wiersma, J.D. Wilkinson, H.C. Williams, S.R.M. Williams, E. Witt, F. Wolfe, A.D. Woolf, S. Wulf, P.-H. Yeh, A.K.M. Zaidi, Z.-J. Zheng, D. Zonies, A.D. Lopez, C.J.L. Murray, M. Moradi-Lakeh

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Abstract

[Truncated abstract] Background : Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs). Methods : Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis...
Original languageEnglish
Pages (from-to)2163-2196
JournalThe Lancet
Volume380
Issue number9859
DOIs
Publication statusPublished - 15 Dec 2012

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