Xpert MTB/RIF testing of stool samples for the diagnosis of pulmonary tuberculosis in children

Mark P. Nicol; Karalene Spiers; Lesley Workman; Washiefa Isaacs; Jacinta Munro; Faye Black; Widaad Zemanay; Heather J. Zar

doi:10.1093/cid/cit230

Xpert MTB/RIF testing of stool samples for the diagnosis of pulmonary tuberculosis in children

Mark P. Nicol, Karalene Spiers, Lesley Workman, Washiefa Isaacs, Jacinta Munro, Faye Black, Widaad Zemanay, Heather J. Zar

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

In a pilot accuracy study, stool Xpert testing from 115 children with suspected pulmonary tuberculosis (PTB) detected 8/17 (47%) culture-confirmed tuberculosis cases, including 4/5 (80%) human immunodeficiency virus (HIV)-infected and 4/12 (33%) HIV-uninfected children. Sputum Xpert detected 11/17 (65%) cases. Stool holds promise for PTB diagnosis in HIV-infected children.

Original language	English
Pages (from-to)	E18-E21
Journal	Clinical Infectious Diseases
Volume	57
Issue number	3
DOIs	https://doi.org/10.1093/cid/cit230
Publication status	Published - 1 Aug 2013
Externally published	Yes

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10.1093/cid/cit230Licence: CC BY

Cite this

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abstract = "In a pilot accuracy study, stool Xpert testing from 115 children with suspected pulmonary tuberculosis (PTB) detected 8/17 (47%) culture-confirmed tuberculosis cases, including 4/5 (80%) human immunodeficiency virus (HIV)-infected and 4/12 (33%) HIV-uninfected children. Sputum Xpert detected 11/17 (65%) cases. Stool holds promise for PTB diagnosis in HIV-infected children.",

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AU - Nicol, Mark P.

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AU - Workman, Lesley

AU - Isaacs, Washiefa

AU - Munro, Jacinta

AU - Black, Faye

AU - Zemanay, Widaad

AU - Zar, Heather J.

PY - 2013/8/1

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N2 - In a pilot accuracy study, stool Xpert testing from 115 children with suspected pulmonary tuberculosis (PTB) detected 8/17 (47%) culture-confirmed tuberculosis cases, including 4/5 (80%) human immunodeficiency virus (HIV)-infected and 4/12 (33%) HIV-uninfected children. Sputum Xpert detected 11/17 (65%) cases. Stool holds promise for PTB diagnosis in HIV-infected children.

AB - In a pilot accuracy study, stool Xpert testing from 115 children with suspected pulmonary tuberculosis (PTB) detected 8/17 (47%) culture-confirmed tuberculosis cases, including 4/5 (80%) human immunodeficiency virus (HIV)-infected and 4/12 (33%) HIV-uninfected children. Sputum Xpert detected 11/17 (65%) cases. Stool holds promise for PTB diagnosis in HIV-infected children.

KW - Children

KW - Diagnosis

KW - Stool

KW - Tuberculosis

KW - Xpert

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JF - Clinical Infectious Diseases

IS - 3

ER -

Xpert MTB/RIF testing of stool samples for the diagnosis of pulmonary tuberculosis in children

Abstract

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