Xpert MTB/RIF for rapid diagnosis of tuberculous lymphadenitis from fine-needle-aspiration biopsy specimens

Louis J. Ligthelm, Mark P. Nicol, Kim G.P. Hoek, Rachael Jacobson, Paul D. Van Helden, Ben J. Marais, Robin M. Warren, Colleen A. Wright

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

This study demonstrates the excellent diagnostic accuracy of the Xpert MTB/RIF test in patients with tuberculous lymphadenitis. The test sensitivity and specificity were 96.7% (95% confidence interval [CI], 86.6 to 100%) and 88.9% (95% CI, 69.6 to 100%), respectively, and it correctly identified 6/6 (100%) of the cytology smear-negative/culture-positive cases and 1 of 2 (50%) rifampin-resistant cases.

Original languageEnglish
Pages (from-to)3967-3970
Number of pages4
JournalJournal of Clinical Microbiology
Volume49
Issue number11
DOIs
Publication statusPublished - 1 Nov 2011
Externally publishedYes

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Lymph Node Tuberculosis
Fine Needle Biopsy
Confidence Intervals
Rifampin
Cell Biology
Sensitivity and Specificity

Cite this

Ligthelm, L. J., Nicol, M. P., Hoek, K. G. P., Jacobson, R., Van Helden, P. D., Marais, B. J., ... Wright, C. A. (2011). Xpert MTB/RIF for rapid diagnosis of tuberculous lymphadenitis from fine-needle-aspiration biopsy specimens. Journal of Clinical Microbiology, 49(11), 3967-3970. https://doi.org/10.1128/JCM.01310-11
Ligthelm, Louis J. ; Nicol, Mark P. ; Hoek, Kim G.P. ; Jacobson, Rachael ; Van Helden, Paul D. ; Marais, Ben J. ; Warren, Robin M. ; Wright, Colleen A. / Xpert MTB/RIF for rapid diagnosis of tuberculous lymphadenitis from fine-needle-aspiration biopsy specimens. In: Journal of Clinical Microbiology. 2011 ; Vol. 49, No. 11. pp. 3967-3970.
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Xpert MTB/RIF for rapid diagnosis of tuberculous lymphadenitis from fine-needle-aspiration biopsy specimens. / Ligthelm, Louis J.; Nicol, Mark P.; Hoek, Kim G.P.; Jacobson, Rachael; Van Helden, Paul D.; Marais, Ben J.; Warren, Robin M.; Wright, Colleen A.

In: Journal of Clinical Microbiology, Vol. 49, No. 11, 01.11.2011, p. 3967-3970.

Research output: Contribution to journalArticle

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AU - Van Helden, Paul D.

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