Xpert MTB/RIF for rapid diagnosis of tuberculous lymphadenitis from fine-needle-aspiration biopsy specimens

Louis J. Ligthelm; Mark P. Nicol; Kim G.P. Hoek; Rachael Jacobson; Paul D. Van Helden; Ben J. Marais; Robin M. Warren; Colleen A. Wright

doi:10.1128/JCM.01310-11

Xpert MTB/RIF for rapid diagnosis of tuberculous lymphadenitis from fine-needle-aspiration biopsy specimens

Louis J. Ligthelm, Mark P. Nicol, Kim G.P. Hoek, Rachael Jacobson, Paul D. Van Helden, Ben J. Marais, Robin M. Warren, Colleen A. Wright

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

This study demonstrates the excellent diagnostic accuracy of the Xpert MTB/RIF test in patients with tuberculous lymphadenitis. The test sensitivity and specificity were 96.7% (95% confidence interval [CI], 86.6 to 100%) and 88.9% (95% CI, 69.6 to 100%), respectively, and it correctly identified 6/6 (100%) of the cytology smear-negative/culture-positive cases and 1 of 2 (50%) rifampin-resistant cases.

Original language	English
Pages (from-to)	3967-3970
Number of pages	4
Journal	Journal of Clinical Microbiology
Volume	49
Issue number	11
DOIs	https://doi.org/10.1128/JCM.01310-11
Publication status	Published - 1 Nov 2011
Externally published	Yes

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title = "Xpert MTB/RIF for rapid diagnosis of tuberculous lymphadenitis from fine-needle-aspiration biopsy specimens",

abstract = "This study demonstrates the excellent diagnostic accuracy of the Xpert MTB/RIF test in patients with tuberculous lymphadenitis. The test sensitivity and specificity were 96.7% (95% confidence interval [CI], 86.6 to 100%) and 88.9% (95% CI, 69.6 to 100%), respectively, and it correctly identified 6/6 (100%) of the cytology smear-negative/culture-positive cases and 1 of 2 (50%) rifampin-resistant cases.",

author = "Ligthelm, {Louis J.} and Nicol, {Mark P.} and Hoek, {Kim G.P.} and Rachael Jacobson and {Van Helden}, {Paul D.} and Marais, {Ben J.} and Warren, {Robin M.} and Wright, {Colleen A.}",

year = "2011",

month = nov,

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doi = "10.1128/JCM.01310-11",

language = "English",

volume = "49",

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journal = "Journal of Clinical Microbiology",

issn = "0095-1137",

publisher = "American Society for Microbiology",

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}

Xpert MTB/RIF for rapid diagnosis of tuberculous lymphadenitis from fine-needle-aspiration biopsy specimens. / Ligthelm, Louis J.; Nicol, Mark P.; Hoek, Kim G.P.; Jacobson, Rachael; Van Helden, Paul D.; Marais, Ben J.; Warren, Robin M.; Wright, Colleen A.

In: Journal of Clinical Microbiology, Vol. 49, No. 11, 01.11.2011, p. 3967-3970.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Xpert MTB/RIF for rapid diagnosis of tuberculous lymphadenitis from fine-needle-aspiration biopsy specimens

AU - Ligthelm, Louis J.

AU - Nicol, Mark P.

AU - Hoek, Kim G.P.

AU - Jacobson, Rachael

AU - Van Helden, Paul D.

AU - Marais, Ben J.

AU - Warren, Robin M.

AU - Wright, Colleen A.

PY - 2011/11/1

Y1 - 2011/11/1

N2 - This study demonstrates the excellent diagnostic accuracy of the Xpert MTB/RIF test in patients with tuberculous lymphadenitis. The test sensitivity and specificity were 96.7% (95% confidence interval [CI], 86.6 to 100%) and 88.9% (95% CI, 69.6 to 100%), respectively, and it correctly identified 6/6 (100%) of the cytology smear-negative/culture-positive cases and 1 of 2 (50%) rifampin-resistant cases.

AB - This study demonstrates the excellent diagnostic accuracy of the Xpert MTB/RIF test in patients with tuberculous lymphadenitis. The test sensitivity and specificity were 96.7% (95% confidence interval [CI], 86.6 to 100%) and 88.9% (95% CI, 69.6 to 100%), respectively, and it correctly identified 6/6 (100%) of the cytology smear-negative/culture-positive cases and 1 of 2 (50%) rifampin-resistant cases.

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JF - Journal of Clinical Microbiology

SN - 0095-1137

IS - 11

ER -

Xpert MTB/RIF for rapid diagnosis of tuberculous lymphadenitis from fine-needle-aspiration biopsy specimens

Abstract

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