Xenotransplantation-current status and future perspectives

Emanuele Cozzi, Erika Bosio, Michela Seveso, Marta Vadori, Ermanno Ancona

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

Research efforts have shed light on the immunological obstacles to long-term survival of pig organs transplanted into primates and allowed the identification of targets for specific immune intervention. Accordingly, the development of genetically engineered animals has overcome the hyperacute rejection barrier, with acute humoral xenograft rejection (AHXR) currently remaining the most important immunological obstacle. At this stage, a better control of the elicited anti-pig humoral immune response and avoidance of coagulation disorders are the two primary research fronts being pursued in order to overcome AHXR. Nonetheless, it is encouraging that porcine xenografts can sustain the life of non-human primates for several months. Proactive research aimed at the development of a safer organ source is also underway. It is anticipated that ongoing research in several fields, including accommodation, tolerance, immune suppression and genetic engineering, will result in further improvements in non-human primate survival. However, until convincing efficacy data and a more favourable risk/benefit ratio can be established in relevant animal models, progression to the clinic should not be viewed as an option.

Original languageEnglish
Pages (from-to)99-114
Number of pages16
JournalBritish Medical Bulletin
Volume75-76
DOIs
Publication statusPublished - 2005
Externally publishedYes

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