Worldwide variation in human milk metabolome: Indicators of breast physiology and maternal lifestyle?

VIVO Lacto Active Study Investigators

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Human milk provides essential substrates for the optimal growth and development of a breastfed infant. Besides providing nutrients to the infant, human milk also contains metabolites which form an intricate system between maternal lifestyle, such as the mother’s diet and the gut microbiome, and infant outcomes. This study investigates the variation of these human milk metabolites from five different countries. Human milk samples (n = 109) were collected one month postpartum from Australia, Japan, the USA, Norway, and South Africa and were analyzed by nuclear magnetic resonance. The partial least squares discriminant analysis (PLS-DA) showed separation between either maternal countries of origin or ethnicities. Variation between countries in concentration of metabolites, such as 2-oxoglutarate, creatine, and glutamine, in human milk, between countries, could provide insights into problems, such as mastitis and/or impaired functions of the mammary glands. Several important markers of milk production, such as lactose, betaine, creatine, glutamate, and glutamine, showed good correlation between each metabolite. This work highlights the importance of milk metabolites with respect to maternal lifestyle and the environment, and also provides the framework for future breastfeeding and microbiome studies in a global context.

Original languageEnglish
Article number1151
JournalNutrients
Volume10
Issue number9
DOIs
Publication statusPublished - 1 Sep 2018

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metabolome
Metabolome
Human Milk
breast milk
lifestyle
breasts
Life Style
Breast
physiology
Mothers
metabolites
creatine
Creatine
Glutamine
glutamine
Milk
mammary gland function
Betaine
Mastitis
Microbiota

Cite this

@article{c19a8a4bc5cf4f4c8bdc38ef397253ad,
title = "Worldwide variation in human milk metabolome: Indicators of breast physiology and maternal lifestyle?",
abstract = "Human milk provides essential substrates for the optimal growth and development of a breastfed infant. Besides providing nutrients to the infant, human milk also contains metabolites which form an intricate system between maternal lifestyle, such as the mother’s diet and the gut microbiome, and infant outcomes. This study investigates the variation of these human milk metabolites from five different countries. Human milk samples (n = 109) were collected one month postpartum from Australia, Japan, the USA, Norway, and South Africa and were analyzed by nuclear magnetic resonance. The partial least squares discriminant analysis (PLS-DA) showed separation between either maternal countries of origin or ethnicities. Variation between countries in concentration of metabolites, such as 2-oxoglutarate, creatine, and glutamine, in human milk, between countries, could provide insights into problems, such as mastitis and/or impaired functions of the mammary glands. Several important markers of milk production, such as lactose, betaine, creatine, glutamate, and glutamine, showed good correlation between each metabolite. This work highlights the importance of milk metabolites with respect to maternal lifestyle and the environment, and also provides the framework for future breastfeeding and microbiome studies in a global context.",
keywords = "Human milk, Lactation, Milk metabolites, Milk metabolomics",
author = "{VIVO Lacto Active Study Investigators} and Gay, {Melvin C.L.} and Koleva, {Petya T.} and Slupsky, {Carolyn M.} and {du Toit}, Elloise and Merete Eggesbo and Johnson, {Christine C.} and Ganesa Wegienka and Naoki Shimojo and Campbell, {Dianne E.} and Prescott, {Susan L.} and Daniel Munblit and Geddes, {Donna T.} and Kozyrskyj, {Anita L.} and Cecilie Dahl and Aveni Haynes and Peter Hsu and Charles Mackay and John Penders and Harald Renz and Carel Thijs and Christina West",
year = "2018",
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doi = "10.3390/nu10091151",
language = "English",
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journal = "Nutrients",
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Worldwide variation in human milk metabolome : Indicators of breast physiology and maternal lifestyle? / VIVO Lacto Active Study Investigators.

In: Nutrients, Vol. 10, No. 9, 1151, 01.09.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Worldwide variation in human milk metabolome

T2 - Indicators of breast physiology and maternal lifestyle?

AU - VIVO Lacto Active Study Investigators

AU - Gay, Melvin C.L.

AU - Koleva, Petya T.

AU - Slupsky, Carolyn M.

AU - du Toit, Elloise

AU - Eggesbo, Merete

AU - Johnson, Christine C.

AU - Wegienka, Ganesa

AU - Shimojo, Naoki

AU - Campbell, Dianne E.

AU - Prescott, Susan L.

AU - Munblit, Daniel

AU - Geddes, Donna T.

AU - Kozyrskyj, Anita L.

AU - Dahl, Cecilie

AU - Haynes, Aveni

AU - Hsu, Peter

AU - Mackay, Charles

AU - Penders, John

AU - Renz, Harald

AU - Thijs, Carel

AU - West, Christina

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Human milk provides essential substrates for the optimal growth and development of a breastfed infant. Besides providing nutrients to the infant, human milk also contains metabolites which form an intricate system between maternal lifestyle, such as the mother’s diet and the gut microbiome, and infant outcomes. This study investigates the variation of these human milk metabolites from five different countries. Human milk samples (n = 109) were collected one month postpartum from Australia, Japan, the USA, Norway, and South Africa and were analyzed by nuclear magnetic resonance. The partial least squares discriminant analysis (PLS-DA) showed separation between either maternal countries of origin or ethnicities. Variation between countries in concentration of metabolites, such as 2-oxoglutarate, creatine, and glutamine, in human milk, between countries, could provide insights into problems, such as mastitis and/or impaired functions of the mammary glands. Several important markers of milk production, such as lactose, betaine, creatine, glutamate, and glutamine, showed good correlation between each metabolite. This work highlights the importance of milk metabolites with respect to maternal lifestyle and the environment, and also provides the framework for future breastfeeding and microbiome studies in a global context.

AB - Human milk provides essential substrates for the optimal growth and development of a breastfed infant. Besides providing nutrients to the infant, human milk also contains metabolites which form an intricate system between maternal lifestyle, such as the mother’s diet and the gut microbiome, and infant outcomes. This study investigates the variation of these human milk metabolites from five different countries. Human milk samples (n = 109) were collected one month postpartum from Australia, Japan, the USA, Norway, and South Africa and were analyzed by nuclear magnetic resonance. The partial least squares discriminant analysis (PLS-DA) showed separation between either maternal countries of origin or ethnicities. Variation between countries in concentration of metabolites, such as 2-oxoglutarate, creatine, and glutamine, in human milk, between countries, could provide insights into problems, such as mastitis and/or impaired functions of the mammary glands. Several important markers of milk production, such as lactose, betaine, creatine, glutamate, and glutamine, showed good correlation between each metabolite. This work highlights the importance of milk metabolites with respect to maternal lifestyle and the environment, and also provides the framework for future breastfeeding and microbiome studies in a global context.

KW - Human milk

KW - Lactation

KW - Milk metabolites

KW - Milk metabolomics

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U2 - 10.3390/nu10091151

DO - 10.3390/nu10091151

M3 - Article

VL - 10

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 9

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ER -