World Workshop on Oral Medicine VII: Platelet count and platelet transfusion for invasive dental procedures in thrombocytopenic patients: A systematic review

Jumana Karasneh, Janina Christoforou, Jennifer S. Walker, Maddalena Manfredi, Bella Dave, Pedro Diz Dios, Peter B. Lockhart, Lauren L. Patton

Research output: Chapter in Book/Conference paperConference paper

1 Citation (Scopus)

Abstract

Objectives To evaluate the evidence for a 50,000/mu l platelet count threshold for platelet transfusion for invasive dental procedures in thrombocytopenic patients. Subjects and Methods We searched in MEDLINE/PubMed, EMBASE, the Cochrane Library (Wiley) and Scopus from 1960 through April 2018 for studies on patients with quantitative platelet disorders not related to medical co-morbidities or medications and undergoing invasive dental procedures. Two reviewers conducted assessments independently. Results We found a total of 176 non-duplicate articles, of which 9 cohort studies met our inclusion criteria. The incidence of postoperative bleeding in thrombocytopenic patients was low (4.9%), and we found no difference in bleeding incidence between patients who had platelet transfusion and those who did not. There was no difference in the mean platelet count for patients with and without bleeding. Different modalities are now available to prevent and control bleeding, which may reduce the need for platelet transfusion. Conclusions There is no evidence to support the long-standing dogma of a need for a platelet count >= 50,000/mu l for safe invasive dental procedures. Platelet transfusion effectiveness for haemostasis support could not be determined based on available data. Local measures and antifibrinolytics are the mainstay for the prevention and management of bleeding.

Original languageEnglish
Title of host publicationWorld Workshop on Oral Medicine Proceedings (WWOM Proceedings)
PublisherWiley-Blackwell
Pages174-181
Number of pages8
Volume25
EditionSuppl 1
DOIs
Publication statusPublished - Jun 2019
Event7th World Workshop on Oral Medicine (WWOM) in conjunction with the European-Association-of-Oral-Medicine Meeting - Gothenburg, Sweden
Duration: 22 Sep 201828 Sep 2018

Publication series

NameOral Diseases
PublisherWiley-Blackwell
ISSN (Print)1354-523X

Conference

Conference7th World Workshop on Oral Medicine (WWOM) in conjunction with the European-Association-of-Oral-Medicine Meeting
CountrySweden
CityGothenburg
Period22/09/1828/09/18

Cite this

Karasneh, J., Christoforou, J., Walker, J. S., Manfredi, M., Dave, B., Diz Dios, P., Lockhart, P. B., & Patton, L. L. (2019). World Workshop on Oral Medicine VII: Platelet count and platelet transfusion for invasive dental procedures in thrombocytopenic patients: A systematic review. In World Workshop on Oral Medicine Proceedings (WWOM Proceedings) (Suppl 1 ed., Vol. 25, pp. 174-181). (Oral Diseases). Wiley-Blackwell. https://doi.org/10.1111/odi.13082