Wnt signaling in triple-negative breast cancer

Sö G. Pohl; N. Brook; M. Agostino; F. Arfuso; A. P. Kumar; A. Dharmarajan

doi:10.1038/oncsis.2017.14

Wnt signaling in triple-negative breast cancer

Sö G. Pohl, N. Brook, M. Agostino, F. Arfuso, A. P. Kumar, A. Dharmarajan

Research output: Contribution to journal › Review article › peer-review

226 Citations (Scopus)

Abstract

Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation, proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many cancers. An aggressive subtype of breast cancer, known as triple-negative breast cancer (TNBC), demonstrates dysregulation in canonical and non-canonical Wnt signaling. In this review, we summarize regulators of canonical and non-canonical Wnt signaling, as well as Wnt signaling dysfunction that mediates the progression of TNBC. We review the complex molecular nature of TNBC and the emerging therapies that are currently under investigation for the treatment of this disease.

Original language	English
Article number	e310
Journal	Oncogenesis
Volume	6
Issue number	4
DOIs	https://doi.org/10.1038/oncsis.2017.14
Publication status	Published - 3 Apr 2017
Externally published	Yes

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10.1038/oncsis.2017.14Licence: CC BY

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abstract = "Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation, proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many cancers. An aggressive subtype of breast cancer, known as triple-negative breast cancer (TNBC), demonstrates dysregulation in canonical and non-canonical Wnt signaling. In this review, we summarize regulators of canonical and non-canonical Wnt signaling, as well as Wnt signaling dysfunction that mediates the progression of TNBC. We review the complex molecular nature of TNBC and the emerging therapies that are currently under investigation for the treatment of this disease.",

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AU - Pohl, Sö G.

AU - Brook, N.

AU - Agostino, M.

AU - Arfuso, F.

AU - Kumar, A. P.

AU - Dharmarajan, A.

PY - 2017/4/3

Y1 - 2017/4/3

N2 - Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation, proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many cancers. An aggressive subtype of breast cancer, known as triple-negative breast cancer (TNBC), demonstrates dysregulation in canonical and non-canonical Wnt signaling. In this review, we summarize regulators of canonical and non-canonical Wnt signaling, as well as Wnt signaling dysfunction that mediates the progression of TNBC. We review the complex molecular nature of TNBC and the emerging therapies that are currently under investigation for the treatment of this disease.

AB - Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation, proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many cancers. An aggressive subtype of breast cancer, known as triple-negative breast cancer (TNBC), demonstrates dysregulation in canonical and non-canonical Wnt signaling. In this review, we summarize regulators of canonical and non-canonical Wnt signaling, as well as Wnt signaling dysfunction that mediates the progression of TNBC. We review the complex molecular nature of TNBC and the emerging therapies that are currently under investigation for the treatment of this disease.

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JF - Oncogenesis

IS - 4

M1 - e310

ER -

Wnt signaling in triple-negative breast cancer

Abstract

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