Within-network brain connectivity in Crohn's disease patients with gadolinium deposition in the cerebellum

Carlo A Mallio, Claudia Piervincenzi, Filippo Carducci, Livia Quintiliani, Paul M Parizel, Patrizia Pantano, Carlo C Quattrocchi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


PURPOSE: Patients with Crohn's disease (CD) undergo multiple gadolinium-based contrast agent injections across their lifespan to enhance signal intensity of the intestinal wall and differentiate active from quiescent inflammatory disease. Thus, CD patients are prone to gadolinium accumulation in the brain and represent a non-neurological population to explore gadolinium-related brain toxicity. Possible effects are expected to be greater on the cerebellar network due to the high propensity of the dentate nucleus to accumulate gadolinium. Herein, we provide a whole-brain network analysis of resting-state fMRI dynamics in long-term quiescent CD patients with normal renal function and MRI evidence of gadolinium deposition in the brain.

METHODS: Fifteen patients with CD and 16 healthy age- and gender-matched controls were enrolled in this study. Relevant resting-state networks (RSNs) were identified using independent component analysis (ICA) from functional magnetic resonance imaging data. An unpaired two-sample t test (with age and sex as nuisance variables) was used to investigate between different RSNs. Clusters were determined by using threshold-free cluster enhancement and a family-wise error corrected cluster significance threshold of p 

RESULTS: Patients showed significantly decreased resting-state functional connectivity (p 

CONCLUSION: Our findings suggest a non-significant impact of gadolinium deposition on within-network cerebellar functional connectivity of long-term quiescent CD patients.

Original languageEnglish
Pages (from-to)833-841
Number of pages9
Issue number7
Early online date4 Apr 2020
Publication statusPublished - 1 Jul 2020


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