TY - JOUR
T1 - Willingness to Participate and Associated Factors in a Zika Vaccine Trial in Indonesia
T2 - A Cross-Sectional Study
AU - Harapan, Harapan
AU - Mudatsir, Mudatsir
AU - Yufika, Amanda
AU - Nawawi, Yusuf
AU - Wahyuniati, Nur
AU - Anwar, Samsul
AU - Yusri, Fitria
AU - Haryanti, Novi
AU - Wijayanti, Nanda Putri
AU - Rizal, Rizal
AU - Fitriani, Devi
AU - Maulida, Nurul Fadhliati
AU - Syahriza, Muhammad
AU - Ikram, Ikram
AU - Fandoko, Try Purwo
AU - Syahadah, Muniati
AU - Asrizal, Febrivan Wahyu
AU - Jamil, Kurnia F.
AU - Rajamoorthy, Yogambigai
AU - Wagner, Abram Luther
AU - Groneberg, David Alexander
AU - Kuch, Ulrich
AU - Müller, Ruth
AU - Sasmono, R. Tedjo
AU - Imrie, Allison
PY - 2018/11/18
Y1 - 2018/11/18
N2 - One of the crucial steps during trials for Zika and other vaccines is to recruit participants and to understand how participants' attitudes and sociodemographic characteristics affect willingness to participate (WTP). This study was conducted to assess WTP, its explanatory variables, and the impact of financial compensation on WTP in Indonesia. A health facility-based cross-sectional study was conducted in eleven regencies in the Aceh and West Sumatra provinces of Indonesia. Participants were recruited via a convenience sampling method and were interviewed. The associations between explanatory variables and WTP were assessed using a two-step logistic regression analysis. A total of 1,102 parents were approached, and of these 956 (86.8%) completed the interview and were included in analysis. Of those, 144 (15.1%) were willing to participate in a Zika vaccine trial without a financial compensation. In the multivariate analysis, WTP was tied to an age of more than 50 years old, compared to 20⁻29 years (odds ratio (OR): 5.0; 95% confidence interval (CI): 2.37⁻10.53), to being female (OR: 2.20; 95% CI: 1.11⁻4.37), and to having heard about Zika (OR: 2.41; 95% CI: 1.59⁻3.65). Participants' WTP increased gradually with higher financial compensation. The rate of WTP increased to 62.3% at the highest offer (US$ 350.4), and those who were still unwilling to participate (37.7%) had a poorer attitude towards childhood vaccination. This study highlights that pre-existing knowledge about Zika and attitudes towards childhood vaccination are important in determining community members being willing to participate in a vaccine trial. Financial incentives are still an important factor to enhance participant recruitment during a vaccine trial.
AB - One of the crucial steps during trials for Zika and other vaccines is to recruit participants and to understand how participants' attitudes and sociodemographic characteristics affect willingness to participate (WTP). This study was conducted to assess WTP, its explanatory variables, and the impact of financial compensation on WTP in Indonesia. A health facility-based cross-sectional study was conducted in eleven regencies in the Aceh and West Sumatra provinces of Indonesia. Participants were recruited via a convenience sampling method and were interviewed. The associations between explanatory variables and WTP were assessed using a two-step logistic regression analysis. A total of 1,102 parents were approached, and of these 956 (86.8%) completed the interview and were included in analysis. Of those, 144 (15.1%) were willing to participate in a Zika vaccine trial without a financial compensation. In the multivariate analysis, WTP was tied to an age of more than 50 years old, compared to 20⁻29 years (odds ratio (OR): 5.0; 95% confidence interval (CI): 2.37⁻10.53), to being female (OR: 2.20; 95% CI: 1.11⁻4.37), and to having heard about Zika (OR: 2.41; 95% CI: 1.59⁻3.65). Participants' WTP increased gradually with higher financial compensation. The rate of WTP increased to 62.3% at the highest offer (US$ 350.4), and those who were still unwilling to participate (37.7%) had a poorer attitude towards childhood vaccination. This study highlights that pre-existing knowledge about Zika and attitudes towards childhood vaccination are important in determining community members being willing to participate in a vaccine trial. Financial incentives are still an important factor to enhance participant recruitment during a vaccine trial.
KW - vaccine acceptance
KW - vaccine trial
KW - willingness to participate
KW - Zika
KW - Zika vaccine
UR - http://www.scopus.com/inward/record.url?scp=85056723856&partnerID=8YFLogxK
U2 - 10.3390/v10110648
DO - 10.3390/v10110648
M3 - Article
C2 - 30453663
AN - SCOPUS:85056723856
VL - 10
JO - Viruses
JF - Viruses
SN - 1999-4915
IS - 11
ER -