Wide-field quantitative micro-elastography of human breast tissue

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to insufficient surgical margins in the initial procedure. We have developed a wide-field quantitative micro-elastography system for the assessment of tumor margins. In this technique, we map tissue elasticity over a field-of-view of ~46 × 46 mm. We performed wide-field quantitative micro-elastography on thirteen specimens of freshly excised tissue acquired from patients undergoing mastectomy. We present wide-field optical coherence tomography (OCT) images, qualitative (strain) micro-elastograms and quantitative (elasticity) micro-elastograms, acquired in 10 minutes. We demonstrate that wide-field quantitative micro-elastography can extend the range of tumors visible using OCT-based elastography by providing contrast not present in either OCT or qualitative microelastography and, in addition, can reduce imaging artifacts caused by a lack of contact between tissue and the imaging window. Also, we describe how the combined evaluation of OCT, qualitative micro-elastograms and quantitative micro-elastograms can improve the visualization of tumor.

Original languageEnglish
Article number#315501
Pages (from-to)1082-1096
Number of pages15
JournalBiomedical Optics Express
Volume9
Issue number3
DOIs
Publication statusPublished - 1 Mar 2018

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Elasticity Imaging Techniques
breast
Breast
tomography
tumors
Optical Coherence Tomography
surgery
margins
elastic properties
Elasticity
field of view
artifacts
Neoplasms
Segmental Mastectomy
evaluation
Mastectomy
Artifacts

Cite this

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title = "Wide-field quantitative micro-elastography of human breast tissue",
abstract = "Currently, 20-30{\%} of patients undergoing breast-conserving surgery require a second surgery due to insufficient surgical margins in the initial procedure. We have developed a wide-field quantitative micro-elastography system for the assessment of tumor margins. In this technique, we map tissue elasticity over a field-of-view of ~46 × 46 mm. We performed wide-field quantitative micro-elastography on thirteen specimens of freshly excised tissue acquired from patients undergoing mastectomy. We present wide-field optical coherence tomography (OCT) images, qualitative (strain) micro-elastograms and quantitative (elasticity) micro-elastograms, acquired in 10 minutes. We demonstrate that wide-field quantitative micro-elastography can extend the range of tumors visible using OCT-based elastography by providing contrast not present in either OCT or qualitative microelastography and, in addition, can reduce imaging artifacts caused by a lack of contact between tissue and the imaging window. Also, we describe how the combined evaluation of OCT, qualitative micro-elastograms and quantitative micro-elastograms can improve the visualization of tumor.",
author = "Allen, {Wes M.} and Kennedy, {Kelsey M.} and Qi Fang and Lixin Chin and Andrea Curatolo and Lucinda Watts and Renate Zilkens and Chin, {Synn Lynn} and Dessauvagie, {Benjamin F.} and Bruce Latham and Saunders, {Christobel M.} and Kennedy, {Brendan F.}",
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Wide-field quantitative micro-elastography of human breast tissue. / Allen, Wes M.; Kennedy, Kelsey M.; Fang, Qi; Chin, Lixin; Curatolo, Andrea; Watts, Lucinda; Zilkens, Renate; Chin, Synn Lynn; Dessauvagie, Benjamin F.; Latham, Bruce; Saunders, Christobel M.; Kennedy, Brendan F.

In: Biomedical Optics Express, Vol. 9, No. 3, #315501, 01.03.2018, p. 1082-1096.

Research output: Contribution to journalArticle

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AU - Allen, Wes M.

AU - Kennedy, Kelsey M.

AU - Fang, Qi

AU - Chin, Lixin

AU - Curatolo, Andrea

AU - Watts, Lucinda

AU - Zilkens, Renate

AU - Chin, Synn Lynn

AU - Dessauvagie, Benjamin F.

AU - Latham, Bruce

AU - Saunders, Christobel M.

AU - Kennedy, Brendan F.

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AB - Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to insufficient surgical margins in the initial procedure. We have developed a wide-field quantitative micro-elastography system for the assessment of tumor margins. In this technique, we map tissue elasticity over a field-of-view of ~46 × 46 mm. We performed wide-field quantitative micro-elastography on thirteen specimens of freshly excised tissue acquired from patients undergoing mastectomy. We present wide-field optical coherence tomography (OCT) images, qualitative (strain) micro-elastograms and quantitative (elasticity) micro-elastograms, acquired in 10 minutes. We demonstrate that wide-field quantitative micro-elastography can extend the range of tumors visible using OCT-based elastography by providing contrast not present in either OCT or qualitative microelastography and, in addition, can reduce imaging artifacts caused by a lack of contact between tissue and the imaging window. Also, we describe how the combined evaluation of OCT, qualitative micro-elastograms and quantitative micro-elastograms can improve the visualization of tumor.

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