Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins

Wes M. Allen; Lixin Chin; Philip Wijesinghe; Rodney Kirk; B. Latham; David Sampson; Christobel Saunders; Brendan Kennedy

doi:10.1364/BOE.7.004139

Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins

Wes M. Allen, Lixin Chin, Philip Wijesinghe, Rodney Kirk, B. Latham, David Sampson, Christobel Saunders, Brendan Kennedy

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Abstract

Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a wide-aperture annular actuator with an internal diameter of 65 mm. We demonstrate feasibility by presenting elastograms recorded from freshly excised human breast tissue, including from a mastectomy, lumpectomies and a cavity shaving.

© 2016 Optical Society of America

Original language	English
Pages (from-to)	4139-4153
Number of pages	15
Journal	Biomedical Optics Express
Volume	7
Issue number	10
DOIs	https://doi.org/10.1364/BOE.7.004139
Publication status	Published - 1 Oct 2016

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Allen, W. M., Chin, L., Wijesinghe, P., Kirk, R., Latham, B., Sampson, D., Saunders, C., & Kennedy, B. (2016). Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins. Biomedical Optics Express, 7(10), 4139-4153. https://doi.org/10.1364/BOE.7.004139

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abstract = "Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a wide-aperture annular actuator with an internal diameter of 65 mm. We demonstrate feasibility by presenting elastograms recorded from freshly excised human breast tissue, including from a mastectomy, lumpectomies and a cavity shaving.{\textcopyright} 2016 Optical Society of America",

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AU - Sampson, David

AU - Saunders, Christobel

AU - Kennedy, Brendan

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AB - Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a wide-aperture annular actuator with an internal diameter of 65 mm. We demonstrate feasibility by presenting elastograms recorded from freshly excised human breast tissue, including from a mastectomy, lumpectomies and a cavity shaving.© 2016 Optical Society of America

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