TY - JOUR
T1 - Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins
AU - Allen, Wes M.
AU - Chin, Lixin
AU - Wijesinghe, Philip
AU - Kirk, Rodney
AU - Latham, B.
AU - Sampson, David
AU - Saunders, Christobel
AU - Kennedy, Brendan
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a wide-aperture annular actuator with an internal diameter of 65 mm. We demonstrate feasibility by presenting elastograms recorded from freshly excised human breast tissue, including from a mastectomy, lumpectomies and a cavity shaving.© 2016 Optical Society of America
AB - Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a wide-aperture annular actuator with an internal diameter of 65 mm. We demonstrate feasibility by presenting elastograms recorded from freshly excised human breast tissue, including from a mastectomy, lumpectomies and a cavity shaving.© 2016 Optical Society of America
U2 - 10.1364/BOE.7.004139
DO - 10.1364/BOE.7.004139
M3 - Article
C2 - 27867721
VL - 7
SP - 4139
EP - 4153
JO - Biomedical Optics Express
JF - Biomedical Optics Express
SN - 2156-7085
IS - 10
M1 - #268575
ER -
