Projects per year
Impetigo is common in remote Indigenous children of northern Australia, with the primary driver in this context being Streptococcus pyogenes [or group A Streptococcus (GAS)]. To reduce the high burden of impetigo, the transmission dynamics of GAS must be more clearly elucidated. We performed whole genome sequencing on 31 GAS isolates collected in a single community from children in 11 households with â2 GAS-infected children. We aimed to determine whether transmission was occurring principally within households or across the community. The 31 isolates were represented by nine multilocus sequence types and isolates within each sequence type differed from one another by only 0-3 single nucleotide polymorphisms. There was evidence of extensive transmission both within households and across the community. Our findings suggest that strategies to reduce the burden of impetigo in this setting will need to extend beyond individual households, and incorporate multi-faceted, community-wide approaches.
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- 2 Finished
Improving Delivery of Secondary Prophylaxis for Rheumatic Heart Disease - A Stepped Wedge Community Randomised Trial
Carapetis, J., Maguire, G., Bailie, R., Currie, B., Kirby, A., Johnston, V., Edwards, K. & Ralph, A.
1/01/12 → 31/12/16