Whole blood gene expression profile associated with spontaneous preterm birth in women with threatened preterm labor

Y. Heng, Craig Pennell, H. Chua, J.E. Perkins, S. Lye

    Research output: Contribution to journalArticlepeer-review

    53 Citations (Scopus)

    Abstract

    Threatened preterm labor (TPTL) is defined as persistent premature uterine contractions between 20 and 37 weeks of gestation and is the most common condition that requires hospitalization during pregnancy. Most of these TPTL women continue their pregnancies to term while only an estimated 5% will deliver a premature baby within ten days. The aim of this work was to study differential whole blood gene expression associated with spontaneous preterm birth (sPTB) within 48 hours of hospital admission. Peripheral blood was collected at point of hospital admission from 154 women with TPTL before any medical treatment. Microarrays were utilized to investigate differential whole blood gene expression between TPTL women who did (n = 48) or did not have a sPTB (n = 106) within 48 hours of admission. Total leukocyte and neutrophil counts were significantly higher (35% and 41% respectively) in women who had sPTB than women who did not deliver within 48 hours (p
    Original languageEnglish
    Article numbere96901
    JournalPLoS One
    Volume9
    Issue number5
    DOIs
    Publication statusPublished - 2014

    Fingerprint

    Dive into the research topics of 'Whole blood gene expression profile associated with spontaneous preterm birth in women with threatened preterm labor'. Together they form a unique fingerprint.

    Cite this