White matter hyperintensities are significantly associated with cortical atrophy in Alzheimer's disease

A.A. Capizzano, L. Acion, T. Bekinschtein, M. Furman, H. Gomila, A. Martinez, R. Mizrahi, Sergio Starkstein

    Research output: Contribution to journalArticle

    93 Citations (Scopus)

    Abstract

    Background and objective: Methodological variability in the assessment of white matter hyperintensities (WMH) in dementia may explain inconsistent reports of its prevalence and impact on cognition. We used a method of brain MRI segmentation for quantifying both tissue and WMH volumes in Alzheimer’s disease (AD) and examined the association between WMH and structural and cognitive variables.Methods: A consecutive series of 81 patients meeting NINCDS-ADRDA criteria for probable AD was studied. Nineteen healthy volunteers of comparable age served as the control group. Patients had a complete neurological and neuropsychological evaluation, and a three dimensional MRI was obtained. Images were segmented into grey matter, white matter, and cerebrospinal fluid. WMH were edited on segmented images, and lobar assignments were based on Talairach coordinates.Results: Mild and moderate to severe AD patients had significantly more WMH than controls (p
    Original languageEnglish
    Pages (from-to)822-827
    JournalJournal of Neurology, Neurosurgery and Psychiatry
    Volume75
    Issue number6
    DOIs
    Publication statusPublished - 2004

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