White matter hyperintensities are significantly associated with cortical atrophy in Alzheimer's disease

A.A. Capizzano; L. Acion; T. Bekinschtein; M. Furman; H. Gomila; A. Martinez; R. Mizrahi; Sergio Starkstein

doi:10.1136/jnnp.2003.019273

White matter hyperintensities are significantly associated with cortical atrophy in Alzheimer's disease

A.A. Capizzano, L. Acion, T. Bekinschtein, M. Furman, H. Gomila, A. Martinez, R. Mizrahi, Sergio Starkstein

Research output: Contribution to journal › Article › peer-review

113 Citations (Scopus)

Abstract

Background and objective: Methodological variability in the assessment of white matter hyperintensities (WMH) in dementia may explain inconsistent reports of its prevalence and impact on cognition. We used a method of brain MRI segmentation for quantifying both tissue and WMH volumes in Alzheimer’s disease (AD) and examined the association between WMH and structural and cognitive variables.Methods: A consecutive series of 81 patients meeting NINCDS-ADRDA criteria for probable AD was studied. Nineteen healthy volunteers of comparable age served as the control group. Patients had a complete neurological and neuropsychological evaluation, and a three dimensional MRI was obtained. Images were segmented into grey matter, white matter, and cerebrospinal fluid. WMH were edited on segmented images, and lobar assignments were based on Talairach coordinates.Results: Mild and moderate to severe AD patients had significantly more WMH than controls (p

Original language	English
Pages (from-to)	822-827
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	75
Issue number	6
DOIs	https://doi.org/10.1136/jnnp.2003.019273
Publication status	Published - 2004

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abstract = "Background and objective: Methodological variability in the assessment of white matter hyperintensities (WMH) in dementia may explain inconsistent reports of its prevalence and impact on cognition. We used a method of brain MRI segmentation for quantifying both tissue and WMH volumes in Alzheimer{\textquoteright}s disease (AD) and examined the association between WMH and structural and cognitive variables.Methods: A consecutive series of 81 patients meeting NINCDS-ADRDA criteria for probable AD was studied. Nineteen healthy volunteers of comparable age served as the control group. Patients had a complete neurological and neuropsychological evaluation, and a three dimensional MRI was obtained. Images were segmented into grey matter, white matter, and cerebrospinal fluid. WMH were edited on segmented images, and lobar assignments were based on Talairach coordinates.Results: Mild and moderate to severe AD patients had significantly more WMH than controls (p",

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T1 - White matter hyperintensities are significantly associated with cortical atrophy in Alzheimer's disease

AU - Capizzano, A.A.

AU - Acion, L.

AU - Bekinschtein, T.

AU - Furman, M.

AU - Gomila, H.

AU - Martinez, A.

AU - Mizrahi, R.

AU - Starkstein, Sergio

PY - 2004

Y1 - 2004

N2 - Background and objective: Methodological variability in the assessment of white matter hyperintensities (WMH) in dementia may explain inconsistent reports of its prevalence and impact on cognition. We used a method of brain MRI segmentation for quantifying both tissue and WMH volumes in Alzheimer’s disease (AD) and examined the association between WMH and structural and cognitive variables.Methods: A consecutive series of 81 patients meeting NINCDS-ADRDA criteria for probable AD was studied. Nineteen healthy volunteers of comparable age served as the control group. Patients had a complete neurological and neuropsychological evaluation, and a three dimensional MRI was obtained. Images were segmented into grey matter, white matter, and cerebrospinal fluid. WMH were edited on segmented images, and lobar assignments were based on Talairach coordinates.Results: Mild and moderate to severe AD patients had significantly more WMH than controls (p

AB - Background and objective: Methodological variability in the assessment of white matter hyperintensities (WMH) in dementia may explain inconsistent reports of its prevalence and impact on cognition. We used a method of brain MRI segmentation for quantifying both tissue and WMH volumes in Alzheimer’s disease (AD) and examined the association between WMH and structural and cognitive variables.Methods: A consecutive series of 81 patients meeting NINCDS-ADRDA criteria for probable AD was studied. Nineteen healthy volunteers of comparable age served as the control group. Patients had a complete neurological and neuropsychological evaluation, and a three dimensional MRI was obtained. Images were segmented into grey matter, white matter, and cerebrospinal fluid. WMH were edited on segmented images, and lobar assignments were based on Talairach coordinates.Results: Mild and moderate to severe AD patients had significantly more WMH than controls (p

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DO - 10.1136/jnnp.2003.019273

M3 - Article

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JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

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ER -

White matter hyperintensities are significantly associated with cortical atrophy in Alzheimer's disease

Abstract

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