When is Alzheimer's not dementia - Cochrane commentary on the National Institute on Ageing and Alzheimer's Association Research Framework for Alzheimer's Disease

Jenny McCleery, Leon Flicker, Edo Richard, Terence J. Quinn

Research output: Contribution to journalReview article

10 Citations (Scopus)
93 Downloads (Pure)

Abstract

Early 2018 saw the release of new diagnostic guidance on Alzheimer's disease from the National Institute on Ageing and the Alzheimer's Association (NIA-AA). This proposed research framework represents a fundamental change in how we think about Alzheimer's disease, moving from diagnosis based on clinical features to diagnosis based solely on biomarkers. These recommendations are contentious and have important implications for patients, clinicians, policy makers and the pharmaceutical industry. In this commentary, we offer a summary of the NIA-AA research framework. We then focus on five key areas: divorcing neuropathology from the clinical syndrome; the emphasis placed on one dementia subtype; validity of available biomarkers; the changing meaning of the term 'Alzheimer's disease'; and the potential for a research framework to influence clinical practice.

Original languageEnglish
Pages (from-to)174-177
Number of pages4
JournalAge and Ageing
Volume48
Issue number2
DOIs
Publication statusPublished - 1 Mar 2019

Fingerprint Dive into the research topics of 'When is Alzheimer's not dementia - Cochrane commentary on the National Institute on Ageing and Alzheimer's Association Research Framework for Alzheimer's Disease'. Together they form a unique fingerprint.

  • Cite this