When do myopia genes have their effect? Comparison of genetic risks between children and adults

J.W.L. Tideman, Q. Fan, J.R. Polling, X. Guo, Seyhan Yazar, A. Khawaja, R. Höhn, Y. Lu, V.W.V. Jaddoe, K. Yamashiro, M. Yoshikawa, A. Gerhold-Ay, S. Nickels, T. Zeller, M. He, T. Boutin, G. Bencic, V. Vitart, David Mackey, P.J. FosterS. Macgregor, C. Williams, S.M. Saw, J.A. Guggenheim, C.C.W. Klaver

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Abstract

© 2016 WILEY PERIODICALS, INC.Previous studies have identified many genetic loci for refractive error and myopia. We aimed to investigate the effect of these loci on ocular biometry as a function of age in children, adolescents, and adults. The study population consisted of three age groups identified from the international CREAM consortium: 5,490 individuals aged 25 years. All participants had undergone standard ophthalmic examination including measurements of axial length (AL) and corneal radius (CR). We examined the lead SNP at all 39 currently known genetic loci for refractive error identified from genome-wide association studies (GWAS), as well as a combined genetic risk score (GRS). The beta coefficient for association between SNP genotype or GRS versus AL/CR was compared across the three age groups, adjusting for age, sex, and principal components. Analyses were Bonferroni-corrected. In the age group
Original languageEnglish
Pages (from-to)756-66
Number of pages689
JournalGenetic Epidemiology
Volume40
Issue number8
DOIs
Publication statusPublished - 2016

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    Tideman, J. W. L., Fan, Q., Polling, J. R., Guo, X., Yazar, S., Khawaja, A., Höhn, R., Lu, Y., Jaddoe, V. W. V., Yamashiro, K., Yoshikawa, M., Gerhold-Ay, A., Nickels, S., Zeller, T., He, M., Boutin, T., Bencic, G., Vitart, V., Mackey, D., ... Klaver, C. C. W. (2016). When do myopia genes have their effect? Comparison of genetic risks between children and adults. Genetic Epidemiology, 40(8), 756-66. https://doi.org/10.1002/gepi.21999, https://doi.org/10.1002/gepi.21999