What Cardiologists Should Know About Calcium Ion Channels and Their Regulation by Reactive Oxygen Species

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    Ion channels underlie the electrical activity of cells. Calcium channels have a unique functional role, because not only do they participate in this activity, they form the means by which electrical signals are converted to responses within the cell. Calcium channels play an integral role in excitation in the heart and shaping the cardiac action potential. In addition, calcium influx through calcium channels is responsible for initiating contraction. Abnormalities in calcium homeostasis underlie cardiac arrhythmia, contractile dysfunction and cardiac remodelling. Reactive oxygen species participate in the development of pathology by altering the redox state of regulatory proteins. There is now good evidence that reactive oxygen species regulate the function of calcium channels. In this mini-review, the evidence for regulation of calcium channels by reactive oxygen species and implications with respect to pathology are presented. Calcium channels may represent a target for intervention during hypoxic trigger of arrhythmia or chronic pathological remodelling.
    Original languageEnglish
    Pages (from-to)361-372
    JournalHeart, Lung & Circulation
    Volume2007
    Issue number16
    DOIs
    Publication statusPublished - 2007

    Fingerprint

    Calcium Channels
    Reactive Oxygen Species
    Cardiac Arrhythmias
    Pathology
    Calcium
    Ion Channels
    Action Potentials
    Oxidation-Reduction
    Cardiologists
    Homeostasis
    Proteins

    Cite this

    @article{b22a81d645644e8d83e51062f5c5d8f6,
    title = "What Cardiologists Should Know About Calcium Ion Channels and Their Regulation by Reactive Oxygen Species",
    abstract = "Ion channels underlie the electrical activity of cells. Calcium channels have a unique functional role, because not only do they participate in this activity, they form the means by which electrical signals are converted to responses within the cell. Calcium channels play an integral role in excitation in the heart and shaping the cardiac action potential. In addition, calcium influx through calcium channels is responsible for initiating contraction. Abnormalities in calcium homeostasis underlie cardiac arrhythmia, contractile dysfunction and cardiac remodelling. Reactive oxygen species participate in the development of pathology by altering the redox state of regulatory proteins. There is now good evidence that reactive oxygen species regulate the function of calcium channels. In this mini-review, the evidence for regulation of calcium channels by reactive oxygen species and implications with respect to pathology are presented. Calcium channels may represent a target for intervention during hypoxic trigger of arrhythmia or chronic pathological remodelling.",
    author = "Livia Hool",
    year = "2007",
    doi = "10.1016/j.hlc.2007.01.005",
    language = "English",
    volume = "2007",
    pages = "361--372",
    journal = "Heart, Lung & Circulation",
    issn = "1444-2892",
    publisher = "Academic Press",
    number = "16",

    }

    What Cardiologists Should Know About Calcium Ion Channels and Their Regulation by Reactive Oxygen Species. / Hool, Livia.

    In: Heart, Lung & Circulation, Vol. 2007, No. 16, 2007, p. 361-372.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - What Cardiologists Should Know About Calcium Ion Channels and Their Regulation by Reactive Oxygen Species

    AU - Hool, Livia

    PY - 2007

    Y1 - 2007

    N2 - Ion channels underlie the electrical activity of cells. Calcium channels have a unique functional role, because not only do they participate in this activity, they form the means by which electrical signals are converted to responses within the cell. Calcium channels play an integral role in excitation in the heart and shaping the cardiac action potential. In addition, calcium influx through calcium channels is responsible for initiating contraction. Abnormalities in calcium homeostasis underlie cardiac arrhythmia, contractile dysfunction and cardiac remodelling. Reactive oxygen species participate in the development of pathology by altering the redox state of regulatory proteins. There is now good evidence that reactive oxygen species regulate the function of calcium channels. In this mini-review, the evidence for regulation of calcium channels by reactive oxygen species and implications with respect to pathology are presented. Calcium channels may represent a target for intervention during hypoxic trigger of arrhythmia or chronic pathological remodelling.

    AB - Ion channels underlie the electrical activity of cells. Calcium channels have a unique functional role, because not only do they participate in this activity, they form the means by which electrical signals are converted to responses within the cell. Calcium channels play an integral role in excitation in the heart and shaping the cardiac action potential. In addition, calcium influx through calcium channels is responsible for initiating contraction. Abnormalities in calcium homeostasis underlie cardiac arrhythmia, contractile dysfunction and cardiac remodelling. Reactive oxygen species participate in the development of pathology by altering the redox state of regulatory proteins. There is now good evidence that reactive oxygen species regulate the function of calcium channels. In this mini-review, the evidence for regulation of calcium channels by reactive oxygen species and implications with respect to pathology are presented. Calcium channels may represent a target for intervention during hypoxic trigger of arrhythmia or chronic pathological remodelling.

    U2 - 10.1016/j.hlc.2007.01.005

    DO - 10.1016/j.hlc.2007.01.005

    M3 - Article

    VL - 2007

    SP - 361

    EP - 372

    JO - Heart, Lung & Circulation

    JF - Heart, Lung & Circulation

    SN - 1444-2892

    IS - 16

    ER -