Water Disinfection By-Products and Prelabor Rupture of Membranes

Sarah Joyce; Angus Cook; John Newnham; M. Brenters; Chantal Ferguson; Philip Weinstein

doi:10.1093/aje/kwn188

Water Disinfection By-Products and Prelabor Rupture of Membranes

Sarah Joyce, Angus Cook, John Newnham, M. Brenters, Chantal Ferguson, Philip Weinstein

School of Population and Global Health

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The causes of term prelabor rupture of membranes (term PROM) remain poorly defined. The authors conducted a record-based prevalence study to explore a possible relation between disinfection by-products in drinking water and term PROM in an Australian community with spatially variable trihalomethane and nitrate levels. A multilevel statistical model was used to examine the relation between factors operating at the levels of the individual, district, and water distribution zone and the prevalence of PROM at term among 16,229 women in Perth, Western Australia (2002-2004). Adjusted odds ratios for term PROM increased with increasing tertiles of nitrate exposure (moderate exposure: odds ratio = 1.23, 95% confidence interval: 1.03, 1.52; high exposure: odds ratio = 1.47, 95% confidence interval: 1.20, 1.79), but there was no significant relation with exposure to trihalomethanes. This study raises the possibility that water contaminants may promote the development of PROM at term.

Original language	English
Pages (from-to)	514-521
Journal	American Journal of Epidemiology
Volume	168
Issue number	5
DOIs	https://doi.org/10.1093/aje/kwn188
Publication status	Published - 2008

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title = "Water Disinfection By-Products and Prelabor Rupture of Membranes",

abstract = "The causes of term prelabor rupture of membranes (term PROM) remain poorly defined. The authors conducted a record-based prevalence study to explore a possible relation between disinfection by-products in drinking water and term PROM in an Australian community with spatially variable trihalomethane and nitrate levels. A multilevel statistical model was used to examine the relation between factors operating at the levels of the individual, district, and water distribution zone and the prevalence of PROM at term among 16,229 women in Perth, Western Australia (2002-2004). Adjusted odds ratios for term PROM increased with increasing tertiles of nitrate exposure (moderate exposure: odds ratio = 1.23, 95% confidence interval: 1.03, 1.52; high exposure: odds ratio = 1.47, 95% confidence interval: 1.20, 1.79), but there was no significant relation with exposure to trihalomethanes. This study raises the possibility that water contaminants may promote the development of PROM at term.",

author = "Sarah Joyce and Angus Cook and John Newnham and M. Brenters and Chantal Ferguson and Philip Weinstein",

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T1 - Water Disinfection By-Products and Prelabor Rupture of Membranes

AU - Joyce, Sarah

AU - Cook, Angus

AU - Newnham, John

AU - Brenters, M.

AU - Ferguson, Chantal

AU - Weinstein, Philip

PY - 2008

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AB - The causes of term prelabor rupture of membranes (term PROM) remain poorly defined. The authors conducted a record-based prevalence study to explore a possible relation between disinfection by-products in drinking water and term PROM in an Australian community with spatially variable trihalomethane and nitrate levels. A multilevel statistical model was used to examine the relation between factors operating at the levels of the individual, district, and water distribution zone and the prevalence of PROM at term among 16,229 women in Perth, Western Australia (2002-2004). Adjusted odds ratios for term PROM increased with increasing tertiles of nitrate exposure (moderate exposure: odds ratio = 1.23, 95% confidence interval: 1.03, 1.52; high exposure: odds ratio = 1.47, 95% confidence interval: 1.20, 1.79), but there was no significant relation with exposure to trihalomethanes. This study raises the possibility that water contaminants may promote the development of PROM at term.

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DO - 10.1093/aje/kwn188

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JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

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Water Disinfection By-Products and Prelabor Rupture of Membranes

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