Water Disinfection By-Products and Prelabor Rupture of Membranes

Sarah Joyce, Angus Cook, John Newnham, M. Brenters, Chantal Ferguson, Philip Weinstein

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


The causes of term prelabor rupture of membranes (term PROM) remain poorly defined. The authors conducted a record-based prevalence study to explore a possible relation between disinfection by-products in drinking water and term PROM in an Australian community with spatially variable trihalomethane and nitrate levels. A multilevel statistical model was used to examine the relation between factors operating at the levels of the individual, district, and water distribution zone and the prevalence of PROM at term among 16,229 women in Perth, Western Australia (2002-2004). Adjusted odds ratios for term PROM increased with increasing tertiles of nitrate exposure (moderate exposure: odds ratio = 1.23, 95% confidence interval: 1.03, 1.52; high exposure: odds ratio = 1.47, 95% confidence interval: 1.20, 1.79), but there was no significant relation with exposure to trihalomethanes. This study raises the possibility that water contaminants may promote the development of PROM at term.
Original languageEnglish
Pages (from-to)514-521
JournalAmerican Journal of Epidemiology
Issue number5
Publication statusPublished - 2008


Dive into the research topics of 'Water Disinfection By-Products and Prelabor Rupture of Membranes'. Together they form a unique fingerprint.

Cite this