TY - JOUR
T1 - Waspergillamide A, a Nitro depsi-Tetrapeptide Diketopiperazine from an Australian Mud Dauber Wasp-Associated Aspergillus sp. (CMB-W031)
AU - Quezada, Michelle
AU - Shang, Zhuo
AU - Kalansuriya, Pabasara
AU - Salim, Angela A.
AU - Lacey, Ernest
AU - Capon, Robert J.
PY - 2017/4/28
Y1 - 2017/4/28
N2 - Chemical profiling of extracts from a mud dauber wasp-associated fungus, Aspergillus sp. (CMB-W031), revealed a remarkably diverse array of secondary metabolites, with many biosynthetic gene clusters being transcriptionally responsive to specific culture conditions. Chemical fractionation of a jasmine rice cultivation yielded many known fungal metabolites, including the highly cytotoxic (−)-stephacidin B and an unprecedented nonribosomal peptide synthase derived nitro depsi-tetrapeptide diketopiperazine, waspergillamide A (1). All structures were assigned by detailed spectroscopic analysis and, where appropriate, chemical degradation and Marfey’s analysis.
AB - Chemical profiling of extracts from a mud dauber wasp-associated fungus, Aspergillus sp. (CMB-W031), revealed a remarkably diverse array of secondary metabolites, with many biosynthetic gene clusters being transcriptionally responsive to specific culture conditions. Chemical fractionation of a jasmine rice cultivation yielded many known fungal metabolites, including the highly cytotoxic (−)-stephacidin B and an unprecedented nonribosomal peptide synthase derived nitro depsi-tetrapeptide diketopiperazine, waspergillamide A (1). All structures were assigned by detailed spectroscopic analysis and, where appropriate, chemical degradation and Marfey’s analysis.
UR - http://www.scopus.com/inward/record.url?scp=85018453287&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.6b01062
DO - 10.1021/acs.jnatprod.6b01062
M3 - Article
C2 - 28234476
AN - SCOPUS:85018453287
SN - 0163-3864
VL - 80
SP - 1192
EP - 1195
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 4
ER -