Walking and inflammatory markers in individuals screened for type 2 diabetes

T. Yates, M. Davies, E. Brady, D. Webb, T. Gorely, Fiona Bull, D. Talbot, N. Sattar, K. Khunti

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Abstract

Objective:To investigate the association of walking activity with inflammatory markers and fasting insulin in a bi-ethnic population screened for type 2 diabetes in Leicester, United Kingdom, between 2005 and 2006.Method:Physical activity, adipocytokine, high-sensitivity C-reactive protein and fasting insulin measurements were available for 400 individuals screened for type 2 diabetes. Of the 400 participants, 56% were diagnosed with normal glucose control, 36% with prediabetes and 8% with diabetes.Results: Multivariate statistical analysis showed that those who reported walking for at least 30min on at least 5days/week had lower levels of C-reactive protein, interleukin-6, and tumor necrosis factor-α compared to those who reported lower walking activity levels, after adjustment for other modes of moderate-to-vigorous intensity physical activity, age, ethnicity, sex, social deprivation and smoking status. Further adjustment for waist circumference attenuated the association of walking with tumor necrosis factor-α.Conclusion: Walking activity, independent of other forms of physical activity, is associated with lower levels of circulating pro-inflammatory markers.
Original languageEnglish
Pages (from-to)417-421
JournalPreventive Medicine
Volume47
Issue number4
DOIs
Publication statusPublished - 2008

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