Vitreous biomarkers in diabetic retinopathy: A systematic review and meta-analysis

A.K. Mcauley, Paul Sanfilippo, Alex Hewitt, H. Liang, E.L. Lamoureux, J. Wang, P.P. Connell

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The aim of this study was to perform a systematic meta-analysis of biomarkers investigated with diabetic retinopathy (DR) in the vitreous, and to explore the molecular pathway interactions of these markers found to be consistently associated with DR. Relevant databases [PubMed and ISI web of science] were searched for all published articles investigating molecular biomarkers of the vitreous associated with DR. Based on set exclusion/inclusion criteria available data from studies with human vitreous samples were extracted and used for our meta-analysis. The interactions of significant biomarkers in DR were investigated via STRING and KEGG pathway analysis. Our meta-analysis of DR identifies eleven biomarkers as potential therapeutic candidates alternate to current anti-VEGF therapy. Four of these are deemed viable therapeutic targets for PDR; ET receptors (ET A and ET B), anti-PDGF-BB, blocking TGF-β using cell therapy and PEDF. The identification of supplementary or synergistic therapeutic candidates to anti VEGF in the treatment of DR may aid in the development of future treatment trials. © 2014 Elsevier Inc.
Original languageEnglish
Pages (from-to)419-425
JournalJournal of Diabetes and Its Complications
Issue number3
Early online date4 Oct 2013
Publication statusPublished - May 2014


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