Vitamin D, shedding light on the development of disease in peripheral arteries

Paul Norman, J.T. Powell

Research output: Contribution to journalReview article

82 Citations (Scopus)

Abstract

Vitamin D is generally associated with calcium metabolism, especially in the context of uptake in the intestine and the formation and maintenance of bone. However, vitamin D influences a wide range of metabolic systems through both genomic and nongenomic pathways that have an impact on the properties of peripheral arteries. The genomic effects have wide importance for angiogenesis, elastogenesis, and immunomodulation; the nongenomic effects have mainly been observed in the presence of hypertension. Although some vitamin D is essential for cardiovascular health, excess may have detrimental effects, particularly on elastogenesis and inflammation of the arterial wall. Vitamin D is likely to have a role in the paradoxical association between arterial calcification and osteoporosis. This review explores the relationship between vitamin D and a range of physiological and pathological processes relevant to peripheral arteries.
Original languageEnglish
Pages (from-to)39-46
JournalArteriosclerosis, Thrombosis and Vascular Biology
Volume25
Issue number1
DOIs
Publication statusPublished - 2005

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Peripheral Arterial Disease
Vitamin D
Arteries
Physiological Phenomena
Arteritis
Immunomodulation
Pathologic Processes
Osteogenesis
Osteoporosis
Intestines
Maintenance
Hypertension
Calcium
Health

Cite this

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title = "Vitamin D, shedding light on the development of disease in peripheral arteries",
abstract = "Vitamin D is generally associated with calcium metabolism, especially in the context of uptake in the intestine and the formation and maintenance of bone. However, vitamin D influences a wide range of metabolic systems through both genomic and nongenomic pathways that have an impact on the properties of peripheral arteries. The genomic effects have wide importance for angiogenesis, elastogenesis, and immunomodulation; the nongenomic effects have mainly been observed in the presence of hypertension. Although some vitamin D is essential for cardiovascular health, excess may have detrimental effects, particularly on elastogenesis and inflammation of the arterial wall. Vitamin D is likely to have a role in the paradoxical association between arterial calcification and osteoporosis. This review explores the relationship between vitamin D and a range of physiological and pathological processes relevant to peripheral arteries.",
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Vitamin D, shedding light on the development of disease in peripheral arteries. / Norman, Paul; Powell, J.T.

In: Arteriosclerosis, Thrombosis and Vascular Biology, Vol. 25, No. 1, 2005, p. 39-46.

Research output: Contribution to journalReview article

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AU - Powell, J.T.

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AB - Vitamin D is generally associated with calcium metabolism, especially in the context of uptake in the intestine and the formation and maintenance of bone. However, vitamin D influences a wide range of metabolic systems through both genomic and nongenomic pathways that have an impact on the properties of peripheral arteries. The genomic effects have wide importance for angiogenesis, elastogenesis, and immunomodulation; the nongenomic effects have mainly been observed in the presence of hypertension. Although some vitamin D is essential for cardiovascular health, excess may have detrimental effects, particularly on elastogenesis and inflammation of the arterial wall. Vitamin D is likely to have a role in the paradoxical association between arterial calcification and osteoporosis. This review explores the relationship between vitamin D and a range of physiological and pathological processes relevant to peripheral arteries.

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