Vitamin D deficiency at melanoma diagnosis is associated with higher Breslow thickness

C. Wyatt, Robyn Lucas, C. Hurst, M.G. Kimlin

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

© 2015 Wyatt et al. Background: Epidemiological evidence shows that people with thicker, or higher stage, melanomas have lower vitamin D status compared to those with thinner tumours. Evidence from experimental studies is inconsistent, but some suggest that administration of vitamin D metabolites can decrease tumour aggressiveness. Objectives: Determine the relationship between vitamin D status at diagnosis and melanoma thickness (as an indicator of prognosis), in a subtropical setting with high melanoma incidence. Methods: We recruited 100 melanoma patients in Brisbane, Australia within days of their diagnosis. Data on factors previously associated with melanoma risk or prognosis were collected by questionnaire and physical examination. Serum for 25-hydroxyvitamin D3 [25(OH)D] levels was collected prior to wider excision biopsy; histological indicators of prognosis were obtained from pathology reports. We used multivariable logistic regression models to analyse the association between Breslow thickness (≥0.75 mm compared to
Original languageEnglish
Pages (from-to)1-13
JournalPLoS One
Volume10
Issue number5
DOIs
Publication statusPublished - 2015

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