Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age

Graeme Zosky, Prudence Hart, Andrew Whitehouse, Merci Kusel, Wei Ang, Rachel Foong, L. Chen, Patrick Holt, P.D.L. Sly, Graham Hall

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Rationale: Vitamin D deficiency is associated with chronic lung disease. We have previously shown in an in vivo mouse model that maternal vitamin D deficiency is associated with alterations in early life lung structure and function. However, there are limited data to support a relationship between maternal vitamin D deficiency during the early stages of lung development and postnatal lung function in human populations. Objectives: To assess the association between maternal vitamin D deficiency, postnatal lung function, and asthmatic status in a longitudinal birth cohort. Methods: Serum was collected at 16 to 20 weeks' gestation at the time of recruitment in a community-based prospective birth cohort for measurement of vitamin D (25[OH]D). Lung function was assessed by spirometry according to American Thoracic Society guidelines in children at 6 and 14 years of age. Demographic and clinical history data were collected by questionnaire at recruitment and at the follow-up visits. Measurements and Main Results: FVC Z-scores in both sexes (β, 0.007 [95% confidence interval (CI), 0.001-0.013]; P = 0.02) and FEV1 Z-scores in girls (β, 0.007 [95% CI, 0.001-0.013]; P = 0.02) were positively associated with maternal serum 25(OH)D at 6 years of age. These associations were mostly absent at 14 years of age. Maternal vitamin D deficiency was positively associated with asthma at 6 years of age but only in boys (odds ratio, 3.03 [95% CI, 1.02-9.02]; P = 0.04). Conclusions: This study supports the notion that vitamin D deficiency during lung development may impact on postnatal lung growth and increase the risk of developing lung disease. Copyright © 2014 by the American Thoracic Society.
Original languageEnglish
Pages (from-to)571-577
JournalAnnals of the American Thoracic Society
Volume11
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Vitamin D Deficiency
Asthma
Pregnancy
Lung
Mothers
Confidence Intervals
Lung Diseases
Parturition
Spirometry
Serum
Vitamin D
Chronic Disease
Odds Ratio
Demography
Guidelines
Growth
Population

Cite this

Zosky, Graeme ; Hart, Prudence ; Whitehouse, Andrew ; Kusel, Merci ; Ang, Wei ; Foong, Rachel ; Chen, L. ; Holt, Patrick ; Sly, P.D.L. ; Hall, Graham. / Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age. In: Annals of the American Thoracic Society. 2014 ; Vol. 11, No. 4. pp. 571-577.
@article{dab3aca8d4524620bb1294b847a83785,
title = "Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age",
abstract = "Rationale: Vitamin D deficiency is associated with chronic lung disease. We have previously shown in an in vivo mouse model that maternal vitamin D deficiency is associated with alterations in early life lung structure and function. However, there are limited data to support a relationship between maternal vitamin D deficiency during the early stages of lung development and postnatal lung function in human populations. Objectives: To assess the association between maternal vitamin D deficiency, postnatal lung function, and asthmatic status in a longitudinal birth cohort. Methods: Serum was collected at 16 to 20 weeks' gestation at the time of recruitment in a community-based prospective birth cohort for measurement of vitamin D (25[OH]D). Lung function was assessed by spirometry according to American Thoracic Society guidelines in children at 6 and 14 years of age. Demographic and clinical history data were collected by questionnaire at recruitment and at the follow-up visits. Measurements and Main Results: FVC Z-scores in both sexes (β, 0.007 [95{\%} confidence interval (CI), 0.001-0.013]; P = 0.02) and FEV1 Z-scores in girls (β, 0.007 [95{\%} CI, 0.001-0.013]; P = 0.02) were positively associated with maternal serum 25(OH)D at 6 years of age. These associations were mostly absent at 14 years of age. Maternal vitamin D deficiency was positively associated with asthma at 6 years of age but only in boys (odds ratio, 3.03 [95{\%} CI, 1.02-9.02]; P = 0.04). Conclusions: This study supports the notion that vitamin D deficiency during lung development may impact on postnatal lung growth and increase the risk of developing lung disease. Copyright {\circledC} 2014 by the American Thoracic Society.",
author = "Graeme Zosky and Prudence Hart and Andrew Whitehouse and Merci Kusel and Wei Ang and Rachel Foong and L. Chen and Patrick Holt and P.D.L. Sly and Graham Hall",
year = "2014",
doi = "10.1513/AnnalsATS.201312-423OC",
language = "English",
volume = "11",
pages = "571--577",
journal = "Proceedings of the American Thoracic Society",
issn = "2329-6933",
publisher = "American Thoracic Society",
number = "4",

}

Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age. / Zosky, Graeme; Hart, Prudence; Whitehouse, Andrew; Kusel, Merci; Ang, Wei; Foong, Rachel; Chen, L.; Holt, Patrick; Sly, P.D.L.; Hall, Graham.

In: Annals of the American Thoracic Society, Vol. 11, No. 4, 2014, p. 571-577.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age

AU - Zosky, Graeme

AU - Hart, Prudence

AU - Whitehouse, Andrew

AU - Kusel, Merci

AU - Ang, Wei

AU - Foong, Rachel

AU - Chen, L.

AU - Holt, Patrick

AU - Sly, P.D.L.

AU - Hall, Graham

PY - 2014

Y1 - 2014

N2 - Rationale: Vitamin D deficiency is associated with chronic lung disease. We have previously shown in an in vivo mouse model that maternal vitamin D deficiency is associated with alterations in early life lung structure and function. However, there are limited data to support a relationship between maternal vitamin D deficiency during the early stages of lung development and postnatal lung function in human populations. Objectives: To assess the association between maternal vitamin D deficiency, postnatal lung function, and asthmatic status in a longitudinal birth cohort. Methods: Serum was collected at 16 to 20 weeks' gestation at the time of recruitment in a community-based prospective birth cohort for measurement of vitamin D (25[OH]D). Lung function was assessed by spirometry according to American Thoracic Society guidelines in children at 6 and 14 years of age. Demographic and clinical history data were collected by questionnaire at recruitment and at the follow-up visits. Measurements and Main Results: FVC Z-scores in both sexes (β, 0.007 [95% confidence interval (CI), 0.001-0.013]; P = 0.02) and FEV1 Z-scores in girls (β, 0.007 [95% CI, 0.001-0.013]; P = 0.02) were positively associated with maternal serum 25(OH)D at 6 years of age. These associations were mostly absent at 14 years of age. Maternal vitamin D deficiency was positively associated with asthma at 6 years of age but only in boys (odds ratio, 3.03 [95% CI, 1.02-9.02]; P = 0.04). Conclusions: This study supports the notion that vitamin D deficiency during lung development may impact on postnatal lung growth and increase the risk of developing lung disease. Copyright © 2014 by the American Thoracic Society.

AB - Rationale: Vitamin D deficiency is associated with chronic lung disease. We have previously shown in an in vivo mouse model that maternal vitamin D deficiency is associated with alterations in early life lung structure and function. However, there are limited data to support a relationship between maternal vitamin D deficiency during the early stages of lung development and postnatal lung function in human populations. Objectives: To assess the association between maternal vitamin D deficiency, postnatal lung function, and asthmatic status in a longitudinal birth cohort. Methods: Serum was collected at 16 to 20 weeks' gestation at the time of recruitment in a community-based prospective birth cohort for measurement of vitamin D (25[OH]D). Lung function was assessed by spirometry according to American Thoracic Society guidelines in children at 6 and 14 years of age. Demographic and clinical history data were collected by questionnaire at recruitment and at the follow-up visits. Measurements and Main Results: FVC Z-scores in both sexes (β, 0.007 [95% confidence interval (CI), 0.001-0.013]; P = 0.02) and FEV1 Z-scores in girls (β, 0.007 [95% CI, 0.001-0.013]; P = 0.02) were positively associated with maternal serum 25(OH)D at 6 years of age. These associations were mostly absent at 14 years of age. Maternal vitamin D deficiency was positively associated with asthma at 6 years of age but only in boys (odds ratio, 3.03 [95% CI, 1.02-9.02]; P = 0.04). Conclusions: This study supports the notion that vitamin D deficiency during lung development may impact on postnatal lung growth and increase the risk of developing lung disease. Copyright © 2014 by the American Thoracic Society.

U2 - 10.1513/AnnalsATS.201312-423OC

DO - 10.1513/AnnalsATS.201312-423OC

M3 - Article

VL - 11

SP - 571

EP - 577

JO - Proceedings of the American Thoracic Society

JF - Proceedings of the American Thoracic Society

SN - 2329-6933

IS - 4

ER -