Vitamin D and the endocrinology of ageing

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Vitamin D is an important prohormone largely derived from sunlight exposure on the skin. In many older people, vitamin D levels have been found to be insufficient or frankly deficient. Alterations in body composition associated with ageing, such as decreased muscle mass and increased adipose tissue, may also decrease vitamin D levels. Low vitamin D levels are associated with an increased risk of falls and fractures and the conditions of frailty and sarcopenia, but confounding with decreased outdoor exposure from a large range of concomitant diseases partly explains these findings. The benefits of vitamin D supplementation found in randomised trials have largely been confined to frail and disabled older people. There is some evidence that bolus vitamin D supplements that achieve supraphysiological levels may increase the risk of falls.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalCurrent Opinion in Endocrine and Metabolic Research
Volume5
DOIs
Publication statusPublished - 1 Mar 2019

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Endocrinology
Vitamin D
Sarcopenia
Sunlight
Body Composition
Adipose Tissue
Muscles
Skin

Cite this

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abstract = "Vitamin D is an important prohormone largely derived from sunlight exposure on the skin. In many older people, vitamin D levels have been found to be insufficient or frankly deficient. Alterations in body composition associated with ageing, such as decreased muscle mass and increased adipose tissue, may also decrease vitamin D levels. Low vitamin D levels are associated with an increased risk of falls and fractures and the conditions of frailty and sarcopenia, but confounding with decreased outdoor exposure from a large range of concomitant diseases partly explains these findings. The benefits of vitamin D supplementation found in randomised trials have largely been confined to frail and disabled older people. There is some evidence that bolus vitamin D supplements that achieve supraphysiological levels may increase the risk of falls.",
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Vitamin D and the endocrinology of ageing. / Flicker, Leon.

In: Current Opinion in Endocrine and Metabolic Research, Vol. 5, 01.03.2019, p. 7-10.

Research output: Contribution to journalReview article

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AU - Flicker, Leon

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