Vitamin D and immunity

Robyn Lucas, Shelley Gorman, Sian Geldenhuys, Prudence Hart

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

© 2014 Faculty of 1000 Ltd. Vitamin D deficiency has been linked to an increased risk of a wide range of adverse health outcomes. The active form of vitamin D has an important role in calcium metabolism and in bone mineralisation, but the evidence for other health outcomes is mixed, with the strongest effects seen in the weakest epidemiological study designs. There are plausible pathways whereby vitamin D deficiency can impair immune function, resulting in both overactivity and increased risk of autoimmune disease, as well as immune suppression with poorer resistance to infection. Vitamin D status may influence the bacterial flora that constitute the microbiome and affect immune function through this route. Exposure of the skin to ultraviolet radiation causes the production of a range of chemicals, including vitamin D, and new research is exploring possible vitamin D-independent immunomodulatory pathways.
Original languageEnglish
Pages (from-to)1-11
JournalF1000Prime Reports
Volume6
DOIs
Publication statusPublished - 2014

Fingerprint

Vitamin D
Immunity
Vitamin D Deficiency
Physiologic Calcification
Microbiota
Health
Autoimmune Diseases
Epidemiologic Studies
Radiation
Calcium
Skin
Infection
Research

Cite this

Lucas, Robyn ; Gorman, Shelley ; Geldenhuys, Sian ; Hart, Prudence. / Vitamin D and immunity. In: F1000Prime Reports. 2014 ; Vol. 6. pp. 1-11.
@article{348595ee6d2a4f2aaf27d0cb45ba6ff4,
title = "Vitamin D and immunity",
abstract = "{\circledC} 2014 Faculty of 1000 Ltd. Vitamin D deficiency has been linked to an increased risk of a wide range of adverse health outcomes. The active form of vitamin D has an important role in calcium metabolism and in bone mineralisation, but the evidence for other health outcomes is mixed, with the strongest effects seen in the weakest epidemiological study designs. There are plausible pathways whereby vitamin D deficiency can impair immune function, resulting in both overactivity and increased risk of autoimmune disease, as well as immune suppression with poorer resistance to infection. Vitamin D status may influence the bacterial flora that constitute the microbiome and affect immune function through this route. Exposure of the skin to ultraviolet radiation causes the production of a range of chemicals, including vitamin D, and new research is exploring possible vitamin D-independent immunomodulatory pathways.",
author = "Robyn Lucas and Shelley Gorman and Sian Geldenhuys and Prudence Hart",
year = "2014",
doi = "10.12703/P6-118",
language = "English",
volume = "6",
pages = "1--11",
journal = "F1000Prime Reports",
issn = "2051-7599",
publisher = "Faculty of 1000 Ltd",

}

Vitamin D and immunity. / Lucas, Robyn; Gorman, Shelley; Geldenhuys, Sian; Hart, Prudence.

In: F1000Prime Reports, Vol. 6, 2014, p. 1-11.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Vitamin D and immunity

AU - Lucas, Robyn

AU - Gorman, Shelley

AU - Geldenhuys, Sian

AU - Hart, Prudence

PY - 2014

Y1 - 2014

N2 - © 2014 Faculty of 1000 Ltd. Vitamin D deficiency has been linked to an increased risk of a wide range of adverse health outcomes. The active form of vitamin D has an important role in calcium metabolism and in bone mineralisation, but the evidence for other health outcomes is mixed, with the strongest effects seen in the weakest epidemiological study designs. There are plausible pathways whereby vitamin D deficiency can impair immune function, resulting in both overactivity and increased risk of autoimmune disease, as well as immune suppression with poorer resistance to infection. Vitamin D status may influence the bacterial flora that constitute the microbiome and affect immune function through this route. Exposure of the skin to ultraviolet radiation causes the production of a range of chemicals, including vitamin D, and new research is exploring possible vitamin D-independent immunomodulatory pathways.

AB - © 2014 Faculty of 1000 Ltd. Vitamin D deficiency has been linked to an increased risk of a wide range of adverse health outcomes. The active form of vitamin D has an important role in calcium metabolism and in bone mineralisation, but the evidence for other health outcomes is mixed, with the strongest effects seen in the weakest epidemiological study designs. There are plausible pathways whereby vitamin D deficiency can impair immune function, resulting in both overactivity and increased risk of autoimmune disease, as well as immune suppression with poorer resistance to infection. Vitamin D status may influence the bacterial flora that constitute the microbiome and affect immune function through this route. Exposure of the skin to ultraviolet radiation causes the production of a range of chemicals, including vitamin D, and new research is exploring possible vitamin D-independent immunomodulatory pathways.

U2 - 10.12703/P6-118

DO - 10.12703/P6-118

M3 - Article

VL - 6

SP - 1

EP - 11

JO - F1000Prime Reports

JF - F1000Prime Reports

SN - 2051-7599

ER -