Vitamin D and cancer mortality in elderly women

G. Wong, Wai Lim, Joshua Lewis, J.C. Craig, R.M. Turner, Kun Zhu, E. Lim, Richard Prince

    Research output: Contribution to journalArticle

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    Abstract

    © 2015 applies to the data made available in this article, unless otherwise stated. Background: There is increasing evidence that vitamin D deficiency is a risk factor for cancer, however it remains uncertain whether vitamin D deficiency also predisposes to death from cancer. The aim of the study was to determine the association between serum 25-hydroxy-vitamin D (25 (OH) D) concentrations and cancer-specific mortality in a community-based cohort of older post-menopausal women. Methods: Cox proportional regression analyses were conducted to examine the association between serum 25 (OH) D concentrations and the risk of overall and site-specific cancer mortality in a cohort of elderly women. Results: Over a median follow-up time of 10years, a total of 84 cancer deaths were observed. Women with lower serum 25 (OH) D concentrations were at an increased risk of cancer death, but not for incident cancer. The excess risk for cancer death was observed with serum 25 (OH) D concentration less than 64nmol/L (the median value) [adjusted HR: 1.61 (95% CI: 1.02 - 2.54, p=0.04]. For every 30nmol/L reduction in serum 25 (OH) D concentrations, there was a 30% increase in the overall risk of cancer death [adjusted HR: 1.33; 95% CI: 1.03 - 1.72, p=0.02]. The excess risk appeared to be site-specific and greatest in those with haematological cancers [adjusted HR: 2.13: 95% CI: 1.0 - 4.55, p=0.05]. Conclusions: In elderly women, lower serum 25 (OH) D concentrations appear to be an independent risk factor for cancer-specific mortality, but not a risk factor for the development of cancer.
    Original languageEnglish
    Number of pages9
    JournalBMC Cancer
    Volume15
    Issue number106
    DOIs
    Publication statusPublished - 8 Mar 2015

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    Vitamin D
    Mortality
    Neoplasms
    Serum
    Vitamin D Deficiency
    Regression Analysis

    Cite this

    Wong, G. ; Lim, Wai ; Lewis, Joshua ; Craig, J.C. ; Turner, R.M. ; Zhu, Kun ; Lim, E. ; Prince, Richard. / Vitamin D and cancer mortality in elderly women. In: BMC Cancer. 2015 ; Vol. 15, No. 106.
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    title = "Vitamin D and cancer mortality in elderly women",
    abstract = "{\circledC} 2015 applies to the data made available in this article, unless otherwise stated. Background: There is increasing evidence that vitamin D deficiency is a risk factor for cancer, however it remains uncertain whether vitamin D deficiency also predisposes to death from cancer. The aim of the study was to determine the association between serum 25-hydroxy-vitamin D (25 (OH) D) concentrations and cancer-specific mortality in a community-based cohort of older post-menopausal women. Methods: Cox proportional regression analyses were conducted to examine the association between serum 25 (OH) D concentrations and the risk of overall and site-specific cancer mortality in a cohort of elderly women. Results: Over a median follow-up time of 10years, a total of 84 cancer deaths were observed. Women with lower serum 25 (OH) D concentrations were at an increased risk of cancer death, but not for incident cancer. The excess risk for cancer death was observed with serum 25 (OH) D concentration less than 64nmol/L (the median value) [adjusted HR: 1.61 (95{\%} CI: 1.02 - 2.54, p=0.04]. For every 30nmol/L reduction in serum 25 (OH) D concentrations, there was a 30{\%} increase in the overall risk of cancer death [adjusted HR: 1.33; 95{\%} CI: 1.03 - 1.72, p=0.02]. The excess risk appeared to be site-specific and greatest in those with haematological cancers [adjusted HR: 2.13: 95{\%} CI: 1.0 - 4.55, p=0.05]. Conclusions: In elderly women, lower serum 25 (OH) D concentrations appear to be an independent risk factor for cancer-specific mortality, but not a risk factor for the development of cancer.",
    author = "G. Wong and Wai Lim and Joshua Lewis and J.C. Craig and R.M. Turner and Kun Zhu and E. Lim and Richard Prince",
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    language = "English",
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    Vitamin D and cancer mortality in elderly women. / Wong, G.; Lim, Wai; Lewis, Joshua; Craig, J.C.; Turner, R.M.; Zhu, Kun; Lim, E.; Prince, Richard.

    In: BMC Cancer, Vol. 15, No. 106, 08.03.2015.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Vitamin D and cancer mortality in elderly women

    AU - Wong, G.

    AU - Lim, Wai

    AU - Lewis, Joshua

    AU - Craig, J.C.

    AU - Turner, R.M.

    AU - Zhu, Kun

    AU - Lim, E.

    AU - Prince, Richard

    PY - 2015/3/8

    Y1 - 2015/3/8

    N2 - © 2015 applies to the data made available in this article, unless otherwise stated. Background: There is increasing evidence that vitamin D deficiency is a risk factor for cancer, however it remains uncertain whether vitamin D deficiency also predisposes to death from cancer. The aim of the study was to determine the association between serum 25-hydroxy-vitamin D (25 (OH) D) concentrations and cancer-specific mortality in a community-based cohort of older post-menopausal women. Methods: Cox proportional regression analyses were conducted to examine the association between serum 25 (OH) D concentrations and the risk of overall and site-specific cancer mortality in a cohort of elderly women. Results: Over a median follow-up time of 10years, a total of 84 cancer deaths were observed. Women with lower serum 25 (OH) D concentrations were at an increased risk of cancer death, but not for incident cancer. The excess risk for cancer death was observed with serum 25 (OH) D concentration less than 64nmol/L (the median value) [adjusted HR: 1.61 (95% CI: 1.02 - 2.54, p=0.04]. For every 30nmol/L reduction in serum 25 (OH) D concentrations, there was a 30% increase in the overall risk of cancer death [adjusted HR: 1.33; 95% CI: 1.03 - 1.72, p=0.02]. The excess risk appeared to be site-specific and greatest in those with haematological cancers [adjusted HR: 2.13: 95% CI: 1.0 - 4.55, p=0.05]. Conclusions: In elderly women, lower serum 25 (OH) D concentrations appear to be an independent risk factor for cancer-specific mortality, but not a risk factor for the development of cancer.

    AB - © 2015 applies to the data made available in this article, unless otherwise stated. Background: There is increasing evidence that vitamin D deficiency is a risk factor for cancer, however it remains uncertain whether vitamin D deficiency also predisposes to death from cancer. The aim of the study was to determine the association between serum 25-hydroxy-vitamin D (25 (OH) D) concentrations and cancer-specific mortality in a community-based cohort of older post-menopausal women. Methods: Cox proportional regression analyses were conducted to examine the association between serum 25 (OH) D concentrations and the risk of overall and site-specific cancer mortality in a cohort of elderly women. Results: Over a median follow-up time of 10years, a total of 84 cancer deaths were observed. Women with lower serum 25 (OH) D concentrations were at an increased risk of cancer death, but not for incident cancer. The excess risk for cancer death was observed with serum 25 (OH) D concentration less than 64nmol/L (the median value) [adjusted HR: 1.61 (95% CI: 1.02 - 2.54, p=0.04]. For every 30nmol/L reduction in serum 25 (OH) D concentrations, there was a 30% increase in the overall risk of cancer death [adjusted HR: 1.33; 95% CI: 1.03 - 1.72, p=0.02]. The excess risk appeared to be site-specific and greatest in those with haematological cancers [adjusted HR: 2.13: 95% CI: 1.0 - 4.55, p=0.05]. Conclusions: In elderly women, lower serum 25 (OH) D concentrations appear to be an independent risk factor for cancer-specific mortality, but not a risk factor for the development of cancer.

    U2 - 10.1186/s12885-015-1112-5

    DO - 10.1186/s12885-015-1112-5

    M3 - Article

    VL - 15

    JO - BMC Cancer

    JF - BMC Cancer

    SN - 1471-2407

    IS - 106

    ER -