TY - JOUR
T1 - Vitamin D
T2 - A novel protective factor for delirium?
AU - Larsson, Susanna C.
AU - Flicker, Leon
PY - 2019/3/19
Y1 - 2019/3/19
N2 - Delirium is a state of acute brain dysfunction, affecting as many as 50% of older patients in hospital, and is associated with prolonged hospitalization, high health care costs, long-term cognitive decline and dementia, and a substantially increased risk of mortality.(1-3) One postulated mechanism is that delirium results from the breakdown of brain network dynamics triggered by a stressor (e.g., major surgery, general anesthesia, infections, or psychoactive drugs) in individuals with preexisting low brain resilience due to deficits in connectivity or plasticity.(2) Multiple lines of evidence support a strong relationship between delirium and dementia and that these conditions share some pathophysiologic mechanisms, including acetylcholine deficiency, inflammation, and reduced cerebral oxidative metabolism.
AB - Delirium is a state of acute brain dysfunction, affecting as many as 50% of older patients in hospital, and is associated with prolonged hospitalization, high health care costs, long-term cognitive decline and dementia, and a substantially increased risk of mortality.(1-3) One postulated mechanism is that delirium results from the breakdown of brain network dynamics triggered by a stressor (e.g., major surgery, general anesthesia, infections, or psychoactive drugs) in individuals with preexisting low brain resilience due to deficits in connectivity or plasticity.(2) Multiple lines of evidence support a strong relationship between delirium and dementia and that these conditions share some pathophysiologic mechanisms, including acetylcholine deficiency, inflammation, and reduced cerebral oxidative metabolism.
UR - http://www.scopus.com/inward/record.url?scp=85063278791&partnerID=8YFLogxK
U2 - 10.1212/WNL.0000000000007121
DO - 10.1212/WNL.0000000000007121
M3 - Editorial
C2 - 30770428
AN - SCOPUS:85063278791
SN - 0028-3878
VL - 92
SP - 553
EP - 554
JO - Neurology
JF - Neurology
IS - 12
ER -