Vitamin A supplementation in extremely preterm infants to prevent bronchopulmonary dysplasia

Abhijeet Rakshasbhuvankar

Research output: ThesisDoctoral Thesis

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Abstract

Suboptimal vitamin A stores of preterm infants may contribute to the development of bronchopulmonary dysplasia (BPD),a chronic lung disease of prematurity associated with increased mortality and morbidity. My doctoral thesis focuses on enteral supplementation of vitamin A to prevent BPD. It consists of a randomised controlled trial, diagnostic accuracy and prospective observational sub-studies, and systematic reviews. My research demonstrates that enteral water-soluble vitamin A supplementation increases plasma retinol levels in extremely preterm infants but fails to reduce the severity of BPD in Western Australia where baseline enteral vitamin A intake is more than 1500 IU/kg/day.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Pillow, Jane, Supervisor
  • Simmer, Karen, Supervisor
  • Patole, Sanjay, Supervisor
Thesis sponsors
Award date21 Jul 2022
DOIs
Publication statusUnpublished - 2021

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