Vitamin A and cancer prevention II: comparison of the effects of retinol and beta-carotene

Nicholas De Klerk, Arthur Musk, Gina Ambrosini, J.L. Eccles, J. Hansen, Nola Olsen, V.L. Watts, Helen Lund, S.C. Pang, J. Beilby, Michael Hobbs

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Former blue asbestos workers known to be at high risk of asbestos-related diseases, particularly malignant mesothelioma and lung cancer, were enrolled in a chemo-prevention program using vitamin A, Our aims were to compare rates of disease and death in subjects randomly assigned to beta-carotene or retinol, Subjects were assigned randomly to take 30 mg/day beta-carotene (512 subjects) or 25,000 IU/day retinol (512 subjects) and followed up through death and cancer registries from the start of the study in June 1990 till May 1995, Comparison between groups was by Cox regression in both intention-to-treat analyses and efficacy analyses based on treatment actually taken, Median follow-up time was 232 weeks, Four cases of lung cancer and 3 cases of mesothelioma were observed in subjects randomised to retinol and 6 cases of lung cancer and 12 cases of mesothelioma in subjects randomised to beta-carotene. The relative rate of mesothelioma (the most common single cause of death in our study) for those on retinol compared with those on beta-carotene was 0.24 (95% CI 0.07-0.86). In the retinol group, there was also a significantly lower rate for death from all causes but a higher rate of ischaemic heart disease mortality, Similar results were found with efficacy analyses. Our results confirm other findings of a lack of any benefit from administration of large doses of synthetic beta-carotene. The finding of significantly lower rates of mesothelioma among subjects assigned to retinol requires further investigation. (C) 1998 Wiley-Liss, Inc.
Original languageEnglish
Pages (from-to)362-367
JournalInternational Journal of Cancer
Volume75
Issue number3
DOIs
Publication statusPublished - 1998

Fingerprint

beta Carotene
Vitamin A
Mesothelioma
Neoplasms
Lung Neoplasms
Mortality
Cause of Death
Crocidolite Asbestos
Intention to Treat Analysis
Asbestos
Myocardial Ischemia
Registries

Cite this

@article{2cd4732108744a60abb0a02b178bf0df,
title = "Vitamin A and cancer prevention II: comparison of the effects of retinol and beta-carotene",
abstract = "Former blue asbestos workers known to be at high risk of asbestos-related diseases, particularly malignant mesothelioma and lung cancer, were enrolled in a chemo-prevention program using vitamin A, Our aims were to compare rates of disease and death in subjects randomly assigned to beta-carotene or retinol, Subjects were assigned randomly to take 30 mg/day beta-carotene (512 subjects) or 25,000 IU/day retinol (512 subjects) and followed up through death and cancer registries from the start of the study in June 1990 till May 1995, Comparison between groups was by Cox regression in both intention-to-treat analyses and efficacy analyses based on treatment actually taken, Median follow-up time was 232 weeks, Four cases of lung cancer and 3 cases of mesothelioma were observed in subjects randomised to retinol and 6 cases of lung cancer and 12 cases of mesothelioma in subjects randomised to beta-carotene. The relative rate of mesothelioma (the most common single cause of death in our study) for those on retinol compared with those on beta-carotene was 0.24 (95{\%} CI 0.07-0.86). In the retinol group, there was also a significantly lower rate for death from all causes but a higher rate of ischaemic heart disease mortality, Similar results were found with efficacy analyses. Our results confirm other findings of a lack of any benefit from administration of large doses of synthetic beta-carotene. The finding of significantly lower rates of mesothelioma among subjects assigned to retinol requires further investigation. (C) 1998 Wiley-Liss, Inc.",
author = "{De Klerk}, Nicholas and Arthur Musk and Gina Ambrosini and J.L. Eccles and J. Hansen and Nola Olsen and V.L. Watts and Helen Lund and S.C. Pang and J. Beilby and Michael Hobbs",
year = "1998",
doi = "10.1002/(SICI)1097-0215(19980130)75:3<362::AID-IJC6>3.0.CO;2-0",
language = "English",
volume = "75",
pages = "362--367",
journal = "International Journal of Cancer (Predictive Oncology)",
issn = "0020-7136",
publisher = "Blackwell",
number = "3",

}

Vitamin A and cancer prevention II: comparison of the effects of retinol and beta-carotene. / De Klerk, Nicholas; Musk, Arthur; Ambrosini, Gina; Eccles, J.L.; Hansen, J.; Olsen, Nola; Watts, V.L.; Lund, Helen; Pang, S.C.; Beilby, J.; Hobbs, Michael.

In: International Journal of Cancer, Vol. 75, No. 3, 1998, p. 362-367.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Vitamin A and cancer prevention II: comparison of the effects of retinol and beta-carotene

AU - De Klerk, Nicholas

AU - Musk, Arthur

AU - Ambrosini, Gina

AU - Eccles, J.L.

AU - Hansen, J.

AU - Olsen, Nola

AU - Watts, V.L.

AU - Lund, Helen

AU - Pang, S.C.

AU - Beilby, J.

AU - Hobbs, Michael

PY - 1998

Y1 - 1998

N2 - Former blue asbestos workers known to be at high risk of asbestos-related diseases, particularly malignant mesothelioma and lung cancer, were enrolled in a chemo-prevention program using vitamin A, Our aims were to compare rates of disease and death in subjects randomly assigned to beta-carotene or retinol, Subjects were assigned randomly to take 30 mg/day beta-carotene (512 subjects) or 25,000 IU/day retinol (512 subjects) and followed up through death and cancer registries from the start of the study in June 1990 till May 1995, Comparison between groups was by Cox regression in both intention-to-treat analyses and efficacy analyses based on treatment actually taken, Median follow-up time was 232 weeks, Four cases of lung cancer and 3 cases of mesothelioma were observed in subjects randomised to retinol and 6 cases of lung cancer and 12 cases of mesothelioma in subjects randomised to beta-carotene. The relative rate of mesothelioma (the most common single cause of death in our study) for those on retinol compared with those on beta-carotene was 0.24 (95% CI 0.07-0.86). In the retinol group, there was also a significantly lower rate for death from all causes but a higher rate of ischaemic heart disease mortality, Similar results were found with efficacy analyses. Our results confirm other findings of a lack of any benefit from administration of large doses of synthetic beta-carotene. The finding of significantly lower rates of mesothelioma among subjects assigned to retinol requires further investigation. (C) 1998 Wiley-Liss, Inc.

AB - Former blue asbestos workers known to be at high risk of asbestos-related diseases, particularly malignant mesothelioma and lung cancer, were enrolled in a chemo-prevention program using vitamin A, Our aims were to compare rates of disease and death in subjects randomly assigned to beta-carotene or retinol, Subjects were assigned randomly to take 30 mg/day beta-carotene (512 subjects) or 25,000 IU/day retinol (512 subjects) and followed up through death and cancer registries from the start of the study in June 1990 till May 1995, Comparison between groups was by Cox regression in both intention-to-treat analyses and efficacy analyses based on treatment actually taken, Median follow-up time was 232 weeks, Four cases of lung cancer and 3 cases of mesothelioma were observed in subjects randomised to retinol and 6 cases of lung cancer and 12 cases of mesothelioma in subjects randomised to beta-carotene. The relative rate of mesothelioma (the most common single cause of death in our study) for those on retinol compared with those on beta-carotene was 0.24 (95% CI 0.07-0.86). In the retinol group, there was also a significantly lower rate for death from all causes but a higher rate of ischaemic heart disease mortality, Similar results were found with efficacy analyses. Our results confirm other findings of a lack of any benefit from administration of large doses of synthetic beta-carotene. The finding of significantly lower rates of mesothelioma among subjects assigned to retinol requires further investigation. (C) 1998 Wiley-Liss, Inc.

U2 - 10.1002/(SICI)1097-0215(19980130)75:3<362::AID-IJC6>3.0.CO;2-0

DO - 10.1002/(SICI)1097-0215(19980130)75:3<362::AID-IJC6>3.0.CO;2-0

M3 - Article

VL - 75

SP - 362

EP - 367

JO - International Journal of Cancer (Predictive Oncology)

JF - International Journal of Cancer (Predictive Oncology)

SN - 0020-7136

IS - 3

ER -