Vital involvement of a natural killer cell activation receptor in resistance to viral infection

M.G. Brown, A.O. Dokun, J.W. Heusel, H.R.C. Smith, D.L. Beckman, E.A. Blattenberger, C.E. Dubbelde, L.R. Stone, Tony Scalzo, W.M. Yokoyama

Research output: Contribution to journalArticle

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Abstract

Natural killer (NK) cells are lymphocytes that can be distinguished from T and B cells through their involvement in innate immunity and their lack of rearranged antigen receptors. Although NK cells and their receptors were initially characterized in terms of tumor killing in vitro, we have determined that the NK cell activation receptor, Ly-49H, is critically involved in resistance to murine cytomegalovirus in vivo. Ly-49H requires an immunoreceptor tyrosine-based activation motif (ITAM)-containing transmembrane molecule for expression and signal transduction. Thus, NK cells use receptors functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host defense.
Original languageEnglish
Pages (from-to)934-937
JournalScience
Volume292
DOIs
Publication statusPublished - 2001

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Natural Killer Cell Receptors
Virus Diseases
Immunoreceptor Tyrosine-Based Activation Motif
Muromegalovirus
B-Cell Antigen Receptors
Antigen Receptors
T-Cell Antigen Receptor
Innate Immunity
Natural Killer Cells
Signal Transduction
B-Lymphocytes
Lymphocytes
T-Lymphocytes
Neoplasms

Cite this

Brown, M. G., Dokun, A. O., Heusel, J. W., Smith, H. R. C., Beckman, D. L., Blattenberger, E. A., ... Yokoyama, W. M. (2001). Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science, 292, 934-937. https://doi.org/10.1126/science.1060042
Brown, M.G. ; Dokun, A.O. ; Heusel, J.W. ; Smith, H.R.C. ; Beckman, D.L. ; Blattenberger, E.A. ; Dubbelde, C.E. ; Stone, L.R. ; Scalzo, Tony ; Yokoyama, W.M. / Vital involvement of a natural killer cell activation receptor in resistance to viral infection. In: Science. 2001 ; Vol. 292. pp. 934-937.
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abstract = "Natural killer (NK) cells are lymphocytes that can be distinguished from T and B cells through their involvement in innate immunity and their lack of rearranged antigen receptors. Although NK cells and their receptors were initially characterized in terms of tumor killing in vitro, we have determined that the NK cell activation receptor, Ly-49H, is critically involved in resistance to murine cytomegalovirus in vivo. Ly-49H requires an immunoreceptor tyrosine-based activation motif (ITAM)-containing transmembrane molecule for expression and signal transduction. Thus, NK cells use receptors functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host defense.",
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Brown, MG, Dokun, AO, Heusel, JW, Smith, HRC, Beckman, DL, Blattenberger, EA, Dubbelde, CE, Stone, LR, Scalzo, T & Yokoyama, WM 2001, 'Vital involvement of a natural killer cell activation receptor in resistance to viral infection' Science, vol. 292, pp. 934-937. https://doi.org/10.1126/science.1060042

Vital involvement of a natural killer cell activation receptor in resistance to viral infection. / Brown, M.G.; Dokun, A.O.; Heusel, J.W.; Smith, H.R.C.; Beckman, D.L.; Blattenberger, E.A.; Dubbelde, C.E.; Stone, L.R.; Scalzo, Tony; Yokoyama, W.M.

In: Science, Vol. 292, 2001, p. 934-937.

Research output: Contribution to journalArticle

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T1 - Vital involvement of a natural killer cell activation receptor in resistance to viral infection

AU - Brown, M.G.

AU - Dokun, A.O.

AU - Heusel, J.W.

AU - Smith, H.R.C.

AU - Beckman, D.L.

AU - Blattenberger, E.A.

AU - Dubbelde, C.E.

AU - Stone, L.R.

AU - Scalzo, Tony

AU - Yokoyama, W.M.

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AB - Natural killer (NK) cells are lymphocytes that can be distinguished from T and B cells through their involvement in innate immunity and their lack of rearranged antigen receptors. Although NK cells and their receptors were initially characterized in terms of tumor killing in vitro, we have determined that the NK cell activation receptor, Ly-49H, is critically involved in resistance to murine cytomegalovirus in vivo. Ly-49H requires an immunoreceptor tyrosine-based activation motif (ITAM)-containing transmembrane molecule for expression and signal transduction. Thus, NK cells use receptors functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host defense.

U2 - 10.1126/science.1060042

DO - 10.1126/science.1060042

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EP - 937

JO - Science

JF - Science

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Brown MG, Dokun AO, Heusel JW, Smith HRC, Beckman DL, Blattenberger EA et al. Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science. 2001;292:934-937. https://doi.org/10.1126/science.1060042