Viridicatumtoxins: Expanding on a Rare Tetracycline Antibiotic Scaffold

Zhuo Shang, Angela A. Salim, Zeinab Khalil, Michelle Quezada, Paul V. Bernhardt, Robert J. Capon

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Viridicatumtoxins, which belong to a rare class of fungal tetracycline-like mycotoxins, were subjected to comprehensive spectroscopic and chemical analysis, leading to reassignment/assignment of absolute configurations and characterization of a remarkably acid-stable antibiotic scaffold. Structure activity relationship studies revealed exceptional growth inhibitory activity against vancomycin-resistant Enterococci (IC50 40 nM), >270-fold more potent than the commercial antibiotic oxytetracycline.

Original languageEnglish
Pages (from-to)12501-12508
Number of pages8
JournalJournal of Organic Chemistry
Volume80
Issue number24
DOIs
Publication statusPublished - 25 Nov 2015
Externally publishedYes

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