Viridans Group Streptococci in Pediatric Leukemia and Stem Cell Transplant: Review of a Risk-stratified Guideline for Empiric Vancomycin in Febrile Neutropenia

Sandra D. Ruhayel; David A. Foley; Kate Hamilton; Patricia Ferguson; Rishi S. Kotecha; Asha C. Bowen; Daniel K. Yeoh

doi:10.1097/INF.0000000000003210

Viridans Group Streptococci in Pediatric Leukemia and Stem Cell Transplant: Review of a Risk-stratified Guideline for Empiric Vancomycin in Febrile Neutropenia

Sandra D. Ruhayel, David A. Foley, Kate Hamilton, Patricia Ferguson, Rishi S. Kotecha, Asha C. Bowen, Daniel K. Yeoh

Research output: Contribution to journal › Article › peer-review

Abstract

Viridans group streptococci (VGS) are an important cause of sepsis in immunosuppressed children. We reviewed the effectiveness of risk-stratified addition of vancomycin to empiric febrile neutropenia therapy among 107 children with leukemia or undergoing an allogeneic transplant. Of 19 VGS bacteremia episodes, 78.9% were susceptible to risk-stratified antibiotics including 100% from high-risk patients. All blood cultures were flagged positive within 24 hours.

Original language	English
Pages (from-to)	832-834
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	40
Issue number	9
DOIs	https://doi.org/10.1097/INF.0000000000003210
Publication status	Published - Sep 2021

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Ruhayel, Sandra D. ; Foley, David A. ; Hamilton, Kate ; Ferguson, Patricia ; Kotecha, Rishi S. ; Bowen, Asha C. ; Yeoh, Daniel K. / Viridans Group Streptococci in Pediatric Leukemia and Stem Cell Transplant : Review of a Risk-stratified Guideline for Empiric Vancomycin in Febrile Neutropenia. In: Pediatric Infectious Disease Journal. 2021 ; Vol. 40, No. 9. pp. 832-834.

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abstract = "Viridans group streptococci (VGS) are an important cause of sepsis in immunosuppressed children. We reviewed the effectiveness of risk-stratified addition of vancomycin to empiric febrile neutropenia therapy among 107 children with leukemia or undergoing an allogeneic transplant. Of 19 VGS bacteremia episodes, 78.9% were susceptible to risk-stratified antibiotics including 100% from high-risk patients. All blood cultures were flagged positive within 24 hours.",

keywords = "febrile neutropenia, hematopoietic stem cell transplant, leukemia, vancomycin, viridans group streptococci",

author = "Ruhayel, {Sandra D.} and Foley, {David A.} and Kate Hamilton and Patricia Ferguson and Kotecha, {Rishi S.} and Bowen, {Asha C.} and Yeoh, {Daniel K.}",

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language = "English",

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Viridans Group Streptococci in Pediatric Leukemia and Stem Cell Transplant : Review of a Risk-stratified Guideline for Empiric Vancomycin in Febrile Neutropenia. / Ruhayel, Sandra D.; Foley, David A.; Hamilton, Kate; Ferguson, Patricia; Kotecha, Rishi S.; Bowen, Asha C.; Yeoh, Daniel K.

In: Pediatric Infectious Disease Journal, Vol. 40, No. 9, 09.2021, p. 832-834.

Research output: Contribution to journal › Article › peer-review

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T1 - Viridans Group Streptococci in Pediatric Leukemia and Stem Cell Transplant

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AU - Ferguson, Patricia

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AU - Bowen, Asha C.

AU - Yeoh, Daniel K.

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AB - Viridans group streptococci (VGS) are an important cause of sepsis in immunosuppressed children. We reviewed the effectiveness of risk-stratified addition of vancomycin to empiric febrile neutropenia therapy among 107 children with leukemia or undergoing an allogeneic transplant. Of 19 VGS bacteremia episodes, 78.9% were susceptible to risk-stratified antibiotics including 100% from high-risk patients. All blood cultures were flagged positive within 24 hours.

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Viridans Group Streptococci in Pediatric Leukemia and Stem Cell Transplant: Review of a Risk-stratified Guideline for Empiric Vancomycin in Febrile Neutropenia

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