Viral and immunological characterisation of murine cytomegalovirus-induced myocarditis

Jason Lenzo

    Research output: ThesisDoctoral Thesis

    29 Downloads (Pure)


    [Truncated] The aim of this thesis was to characterise and examine various mechanisms involved in the development of murine cytomegalovirus (MCMV)-induced myocarditis with a view to develop potential therapeutic regimes. MCMV induces acute and chronic myocarditis in BALB/c mice, which are genetically susceptible to MCMV, and low levels of acute disease in resistant C57BL/6 mice. The role of virus was studied using the laboratory strain of MCMV, K181, and a wild isolate of MCMV, G4. Whilst MCMV is capable of directly killing myocytes, infectious virus is not detectable in the heart beyond day 6 post-infection (p.i.). Myocytes undergo low levels of apoptosis following virus infection, indicating that apoptosis is not a major cause of the necrosis observed in this disease. The inflammatory infiltrate was identified as being predominantly CD8+ T cells in the foci during the acute and chronic phases of disease in both susceptible and resistant mouse strains. CD4+ T cells and B cells were identified throughout the myocardium in both mouse strains, however, only susceptible BALB/c mice mount a macrophage and neutrophil response in the heart following infection.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Publication statusUnpublished - 2002

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    • This thesis has been made available in the UWA Profiles and Research Repository as part of a UWA Library project to digitise and make available theses completed before 2003. If you are the author of this thesis and would like it removed from the UWA Profiles and Research Repository, please contact


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