Viral and immunological characterisation of murine cytomegalovirus-induced myocarditis

Jason Lenzo

    Research output: ThesisDoctoral Thesis

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    Abstract

    [Truncated] The aim of this thesis was to characterise and examine various mechanisms involved in the development of murine cytomegalovirus (MCMV)-induced myocarditis with a view to develop potential therapeutic regimes. MCMV induces acute and chronic myocarditis in BALB/c mice, which are genetically susceptible to MCMV, and low levels of acute disease in resistant C57BL/6 mice. The role of virus was studied using the laboratory strain of MCMV, K181, and a wild isolate of MCMV, G4. Whilst MCMV is capable of directly killing myocytes, infectious virus is not detectable in the heart beyond day 6 post-infection (p.i.). Myocytes undergo low levels of apoptosis following virus infection, indicating that apoptosis is not a major cause of the necrosis observed in this disease. The inflammatory infiltrate was identified as being predominantly CD8+ T cells in the foci during the acute and chronic phases of disease in both susceptible and resistant mouse strains. CD4+ T cells and B cells were identified throughout the myocardium in both mouse strains, however, only susceptible BALB/c mice mount a macrophage and neutrophil response in the heart following infection.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    DOIs
    Publication statusUnpublished - 2002

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