Ventricular volumes across stages of schizophrenia and other psychoses

Gregor E. Berger, Cali F. Bartholomeusz, Stephen J. Wood, Anthony Ang, Lisa J. Phillips, Tina Proffitt, Warrick J. Brewer, Deidre J. Smith, Barnaby Nelson, Ashleigh Lin, Stefan Borgwardt, Dennis Velakoulis, Alison R. Yung, Patrick D. McGorry, Christos Pantelis

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2 Citations (Scopus)

Abstract

Objective: Ventricular enlargement is common in established schizophrenia; however, data from ultra high-risk for psychosis and first-episode psychosis studies are inconclusive. This study aims to investigate ventricular volumes at different stages of psychosis. Methods: Ventricular volumes were measured using a semi-automated and highly reliable method, for 89 established schizophrenia, 162 first-episode psychosis, 135 ultra high-risk for psychosis and 87 healthy controls using 1.5T magnetic resonance images. Clinical outcome diagnoses for ultra high-risk for psychosis were evaluated at long-term follow-up (mean: 7.5 years). Results: Compared to controls, we identified significant ventricular enlargement of 36.2% in established schizophrenia (p < 0.001). Ventricular enlargement was not significant in first-episode psychosis (6%) or ultra high-risk for psychosis (-3%). Examination across stages of schizophrenia-spectrum diagnoses subgroups revealed a significant linear trend (p = 0.006; established schizophrenia = 36.2%, first-episode psychosis schizophrenia = 18.5%, first-episode psychosis schizophreniform = -4.2% and ultra high-risk for psychosis-schizophrenia converters = -18.5%). Conclusion: Ventricular enlargement is apparent in patients with established schizophrenia but is not a feature at the earliest stages of illness (ultra high-risk for psychosis and first-episode psychosis). Further research is needed to fully characterize the nature and timing of ventricular volume changes early in the course of illness and how these changes impact outcomes.

Original languageEnglish
Pages (from-to)1041-1051
Number of pages11
JournalAustralian and New Zealand Journal of Psychiatry
Volume51
Issue number10
DOIs
Publication statusPublished - 1 Oct 2017

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Psychotic Disorders
Schizophrenia
Magnetic Resonance Spectroscopy

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Berger, G. E., Bartholomeusz, C. F., Wood, S. J., Ang, A., Phillips, L. J., Proffitt, T., ... Pantelis, C. (2017). Ventricular volumes across stages of schizophrenia and other psychoses. Australian and New Zealand Journal of Psychiatry, 51(10), 1041-1051. https://doi.org/10.1177/0004867417715914
Berger, Gregor E. ; Bartholomeusz, Cali F. ; Wood, Stephen J. ; Ang, Anthony ; Phillips, Lisa J. ; Proffitt, Tina ; Brewer, Warrick J. ; Smith, Deidre J. ; Nelson, Barnaby ; Lin, Ashleigh ; Borgwardt, Stefan ; Velakoulis, Dennis ; Yung, Alison R. ; McGorry, Patrick D. ; Pantelis, Christos. / Ventricular volumes across stages of schizophrenia and other psychoses. In: Australian and New Zealand Journal of Psychiatry. 2017 ; Vol. 51, No. 10. pp. 1041-1051.
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title = "Ventricular volumes across stages of schizophrenia and other psychoses",
abstract = "Objective: Ventricular enlargement is common in established schizophrenia; however, data from ultra high-risk for psychosis and first-episode psychosis studies are inconclusive. This study aims to investigate ventricular volumes at different stages of psychosis. Methods: Ventricular volumes were measured using a semi-automated and highly reliable method, for 89 established schizophrenia, 162 first-episode psychosis, 135 ultra high-risk for psychosis and 87 healthy controls using 1.5T magnetic resonance images. Clinical outcome diagnoses for ultra high-risk for psychosis were evaluated at long-term follow-up (mean: 7.5 years). Results: Compared to controls, we identified significant ventricular enlargement of 36.2{\%} in established schizophrenia (p < 0.001). Ventricular enlargement was not significant in first-episode psychosis (6{\%}) or ultra high-risk for psychosis (-3{\%}). Examination across stages of schizophrenia-spectrum diagnoses subgroups revealed a significant linear trend (p = 0.006; established schizophrenia = 36.2{\%}, first-episode psychosis schizophrenia = 18.5{\%}, first-episode psychosis schizophreniform = -4.2{\%} and ultra high-risk for psychosis-schizophrenia converters = -18.5{\%}). Conclusion: Ventricular enlargement is apparent in patients with established schizophrenia but is not a feature at the earliest stages of illness (ultra high-risk for psychosis and first-episode psychosis). Further research is needed to fully characterize the nature and timing of ventricular volume changes early in the course of illness and how these changes impact outcomes.",
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author = "Berger, {Gregor E.} and Bartholomeusz, {Cali F.} and Wood, {Stephen J.} and Anthony Ang and Phillips, {Lisa J.} and Tina Proffitt and Brewer, {Warrick J.} and Smith, {Deidre J.} and Barnaby Nelson and Ashleigh Lin and Stefan Borgwardt and Dennis Velakoulis and Yung, {Alison R.} and McGorry, {Patrick D.} and Christos Pantelis",
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Berger, GE, Bartholomeusz, CF, Wood, SJ, Ang, A, Phillips, LJ, Proffitt, T, Brewer, WJ, Smith, DJ, Nelson, B, Lin, A, Borgwardt, S, Velakoulis, D, Yung, AR, McGorry, PD & Pantelis, C 2017, 'Ventricular volumes across stages of schizophrenia and other psychoses' Australian and New Zealand Journal of Psychiatry, vol. 51, no. 10, pp. 1041-1051. https://doi.org/10.1177/0004867417715914

Ventricular volumes across stages of schizophrenia and other psychoses. / Berger, Gregor E.; Bartholomeusz, Cali F.; Wood, Stephen J.; Ang, Anthony; Phillips, Lisa J.; Proffitt, Tina; Brewer, Warrick J.; Smith, Deidre J.; Nelson, Barnaby; Lin, Ashleigh; Borgwardt, Stefan; Velakoulis, Dennis; Yung, Alison R.; McGorry, Patrick D.; Pantelis, Christos.

In: Australian and New Zealand Journal of Psychiatry, Vol. 51, No. 10, 01.10.2017, p. 1041-1051.

Research output: Contribution to journalArticle

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AU - Berger, Gregor E.

AU - Bartholomeusz, Cali F.

AU - Wood, Stephen J.

AU - Ang, Anthony

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AU - Proffitt, Tina

AU - Brewer, Warrick J.

AU - Smith, Deidre J.

AU - Nelson, Barnaby

AU - Lin, Ashleigh

AU - Borgwardt, Stefan

AU - Velakoulis, Dennis

AU - Yung, Alison R.

AU - McGorry, Patrick D.

AU - Pantelis, Christos

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Objective: Ventricular enlargement is common in established schizophrenia; however, data from ultra high-risk for psychosis and first-episode psychosis studies are inconclusive. This study aims to investigate ventricular volumes at different stages of psychosis. Methods: Ventricular volumes were measured using a semi-automated and highly reliable method, for 89 established schizophrenia, 162 first-episode psychosis, 135 ultra high-risk for psychosis and 87 healthy controls using 1.5T magnetic resonance images. Clinical outcome diagnoses for ultra high-risk for psychosis were evaluated at long-term follow-up (mean: 7.5 years). Results: Compared to controls, we identified significant ventricular enlargement of 36.2% in established schizophrenia (p < 0.001). Ventricular enlargement was not significant in first-episode psychosis (6%) or ultra high-risk for psychosis (-3%). Examination across stages of schizophrenia-spectrum diagnoses subgroups revealed a significant linear trend (p = 0.006; established schizophrenia = 36.2%, first-episode psychosis schizophrenia = 18.5%, first-episode psychosis schizophreniform = -4.2% and ultra high-risk for psychosis-schizophrenia converters = -18.5%). Conclusion: Ventricular enlargement is apparent in patients with established schizophrenia but is not a feature at the earliest stages of illness (ultra high-risk for psychosis and first-episode psychosis). Further research is needed to fully characterize the nature and timing of ventricular volume changes early in the course of illness and how these changes impact outcomes.

AB - Objective: Ventricular enlargement is common in established schizophrenia; however, data from ultra high-risk for psychosis and first-episode psychosis studies are inconclusive. This study aims to investigate ventricular volumes at different stages of psychosis. Methods: Ventricular volumes were measured using a semi-automated and highly reliable method, for 89 established schizophrenia, 162 first-episode psychosis, 135 ultra high-risk for psychosis and 87 healthy controls using 1.5T magnetic resonance images. Clinical outcome diagnoses for ultra high-risk for psychosis were evaluated at long-term follow-up (mean: 7.5 years). Results: Compared to controls, we identified significant ventricular enlargement of 36.2% in established schizophrenia (p < 0.001). Ventricular enlargement was not significant in first-episode psychosis (6%) or ultra high-risk for psychosis (-3%). Examination across stages of schizophrenia-spectrum diagnoses subgroups revealed a significant linear trend (p = 0.006; established schizophrenia = 36.2%, first-episode psychosis schizophrenia = 18.5%, first-episode psychosis schizophreniform = -4.2% and ultra high-risk for psychosis-schizophrenia converters = -18.5%). Conclusion: Ventricular enlargement is apparent in patients with established schizophrenia but is not a feature at the earliest stages of illness (ultra high-risk for psychosis and first-episode psychosis). Further research is needed to fully characterize the nature and timing of ventricular volume changes early in the course of illness and how these changes impact outcomes.

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KW - ultra high-risk

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Berger GE, Bartholomeusz CF, Wood SJ, Ang A, Phillips LJ, Proffitt T et al. Ventricular volumes across stages of schizophrenia and other psychoses. Australian and New Zealand Journal of Psychiatry. 2017 Oct 1;51(10):1041-1051. https://doi.org/10.1177/0004867417715914