The optimum modality of mechanical ventilation in patients with intra-abdominal hypertension (IAH) remains unknown. In basic preclinical and translational-clinical studies, we show a clear association between IAH and hypoxic respiratory failure with poor short-term outcomes. Additional intra-abdominal volume exponentially increases inspiratory airway pressures. Positive end-expiratory pressure (PEEP) in the presence of IAH improves oxygenation and decreases atelectasis at the cost of overdistended lung and reduced cardiac function. Relative to moderate PEEP, high PEEP is tolerated poorly by patients with IAH. However, an optimal PEEP that predominantly improves oxygenation and prevents atelectasis without causing overdistension or hemodynamic compromise was not found.
|Qualification||Doctor of Philosophy|
|Award date||16 Aug 2021|
|Publication status||Unpublished - 2021|
- Embargoed from 06/09/2021 to 23/11/2021. Made publicly available on 23/11/2021.