Abstract
Leaky blood vessels are a key feature of tumours, impeding effective blood flow, drug delivery and immune destruction. In this thesis, strategies for vessel normalisation were employed to modulate pericytes by cytokine targeting (LIGHT or TNFSF14) and genetic deletion of RGS5 in highly angiogenic mouse models of neuroendocrine pancreatic cancer, lung cancer and melanoma. This thesis, delineates new mechanisms of pericyte-induced vessel normalisation, identifies key pharmacological pathways to induce pericyte maturation and provides new insights into vascular targeting in desmoplastic cancers like pancreatic adenocarcinoma for improved tumour perfusion, enhanced drug delivery and immune cell infiltration.
Original language | English |
---|---|
Qualification | Doctor of Philosophy |
Awarding Institution |
|
Supervisors/Advisors |
|
Thesis sponsors | |
Award date | 14 May 2020 |
DOIs | |
Publication status | Unpublished - 2020 |
Embargo information
- Embargoed from 20/05/2020 to 14/05/2022. Made publicly available on 14/05/2022.