Vascular targeting and remodelling: Improving the blood tumour barrier

Daphne Lakhiani

Research output: ThesisDoctoral Thesis

57 Downloads (Pure)

Abstract

Leaky blood vessels are a key feature of tumours, impeding effective blood flow, drug delivery and immune destruction. In this thesis, strategies for vessel normalisation were employed to modulate pericytes by cytokine targeting (LIGHT or TNFSF14) and genetic deletion of RGS5 in highly angiogenic mouse models of neuroendocrine pancreatic cancer, lung cancer and melanoma. This thesis, delineates new mechanisms of pericyte-induced vessel normalisation, identifies key pharmacological pathways to induce pericyte maturation and provides new insights into vascular targeting in desmoplastic cancers like pancreatic adenocarcinoma for improved tumour perfusion, enhanced drug delivery and immune cell infiltration.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Ganss, Ruth, Supervisor
  • Hamzah, Juliana, Supervisor
Thesis sponsors
Award date14 May 2020
DOIs
Publication statusUnpublished - 2020

Embargo information

  • Embargoed from 20/05/2020 to 14/05/2022. Made publicly available on 14/05/2022.

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