Vascular adaptation to exercise in humans: Role of hemodynamic stimuli

Daniel J. Green, Maria T E Hopman, Jaume Padilla, M. Harold Laughlin, Dick H J Thijssen

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99 Citations (Scopus)
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Abstract

On the 400th anniversary of Harvey’s Lumleian lectures, this review focuses on “hemodynamic” forces associated with the movement of blood through arteries in humans and the functional and structural adaptations that result from repeated episodic exposure to such stimuli. The late 20th century discovery that endothelial cells modify arterial tone via paracrine transduction provoked studies exploring the direct mechanical effects of blood flow and pressure on vascular function and adaptation in vivo. In this review, we address the impact of distinct hemodynamic signals that occur in response to exercise, the interrelationships between these signals, the nature of the adaptive responses that manifest under different physiological conditions, and the implications for human health. Exercise modifies blood flow, luminal shear stress, arterial pressure, and tangential wall stress, all of which can transduce changes in arterial function, diameter, and wall thickness. There are important clinical implications of the adaptation that occurs as a consequence of repeated hemodynamic stimulation associated with exercise training in humans, including impacts on atherosclerotic risk in conduit arteries, the control of blood pressure in resistance vessels, oxygen delivery and diffusion, and microvascular health. Exercise training studies have demonstrated that direct hemodynamic impacts on the health of the artery wall contribute to the well-established decrease in cardiovascular risk attributed to physical activity.

Original languageEnglish
Pages (from-to)495-528
Number of pages34
JournalPhysiological Reviews
Volume97
Issue number2
DOIs
Publication statusPublished - 1 Apr 2017

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Blood Vessels
Hemodynamics
Arteries
Health
Exercise
Blood Pressure
Anniversaries and Special Events
Arterial Pressure
Endothelial Cells
Oxygen

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Green, D. J., Hopman, M. T. E., Padilla, J., Laughlin, M. H., & Thijssen, D. H. J. (2017). Vascular adaptation to exercise in humans: Role of hemodynamic stimuli. Physiological Reviews, 97(2), 495-528. https://doi.org/10.1152/physrev.00014.2016
Green, Daniel J. ; Hopman, Maria T E ; Padilla, Jaume ; Laughlin, M. Harold ; Thijssen, Dick H J. / Vascular adaptation to exercise in humans : Role of hemodynamic stimuli. In: Physiological Reviews. 2017 ; Vol. 97, No. 2. pp. 495-528.
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Green, DJ, Hopman, MTE, Padilla, J, Laughlin, MH & Thijssen, DHJ 2017, 'Vascular adaptation to exercise in humans: Role of hemodynamic stimuli' Physiological Reviews, vol. 97, no. 2, pp. 495-528. https://doi.org/10.1152/physrev.00014.2016

Vascular adaptation to exercise in humans : Role of hemodynamic stimuli. / Green, Daniel J.; Hopman, Maria T E; Padilla, Jaume; Laughlin, M. Harold; Thijssen, Dick H J.

In: Physiological Reviews, Vol. 97, No. 2, 01.04.2017, p. 495-528.

Research output: Contribution to journalArticle

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