Variability of aerosol delivery via spacer devices in young asthmatic children in daily life

H.M. Janssens, Sunalene Devadason, W.C. Hop, Peter Lesouef, J.C. De Jongste, H.A. Tiddens

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96 Citations (Scopus)


Pressurized metered dose inhalers (pMDI) are widely used together with spacers for the treatment of asthma in children, However, the variability of daily medication dose for pMDI/spacer combinations is not known. Electrostatic charge is a potential source of dose variability. Metal spacers have no static charge, This study assessed and compared within-subject variability of aerosol delivery of metal and plastic spacers, This was a randomized, crossover study in children with stable asthma aged 1-4 (group I, n=17) and 5-8 (group II, n=16) yrs, In both groups the amount of drug delivered to the mouth by a metal spacer (Nebuchamber(R)) and one of two plastic (polycarbonate) spacers, i.e. Babyhaler(R) in group I and Volumatici(R) in group II was measured, The metal and plastic spacers mere tested at home in a randomized order for 7 days each, using budesonide (200 mu g b.i.d.). Aerosol was collected on a filter positioned between spacer and facemask or mouth. Budesonide on the filter was assessed by high performance liquid chromatography. The mean filter dose for each child (mean+/-SD) during the 7 days was expressed as a percentage of the nominal dose. Within-subject variability was expressed as coefficient of variation (CV).Mean filter dose in group I was 41.7+/-10.1% for Nebuchamber and 26.0+/-4.0% for Babyhaler (p
Original languageEnglish
Pages (from-to)787-91
JournalEuropean Respiratory Journal
Issue number4
Publication statusPublished - 1999


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