Vaccination strategies to enhance immunity in neonates

Tobias R. Kollmann, Arnaud Marchant, Sing Sing Way

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Neonates are particularly susceptible to infection. This vulnerability occurs despite their responsiveness to most vaccines. However, current vaccines do not target the pathogens responsible for most of the severe neonatal infections, and the time it takes to induce protective pathogen-specific immunity after vaccination limits protection in the first days to weeks of life. Alternative strategies include using vaccines to broadly stimulate neonatal immunity in a pathogen-agnostic fashion or vaccinating women during pregnancy to induce protective antibodies that are vertically transferred to offspring within their window of vulnerability. Protection may be further improved by integrating these approaches, namely vaccinating the neonate under the cover of vertically transferred maternal immunity. The rationale for and knowledge gaps related to each of these alternatives are discussed.

Original languageEnglish
Pages (from-to)612-615
Number of pages4
JournalScience
Volume368
Issue number6491
DOIs
Publication statusPublished - 8 May 2020

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