@inbook{eccb43fba272440b895376a167ec0a99,
title = "Using systems genetics to understanding the etiology of complex disease",
abstract = "Here, we discuss Systems Genetics applications for systematic evaluation of candidate causal genes together with follow-up bioinformatics pathway analysis. The aim of this chapter is to illustrate analytic procedures and we provide examples in the context of Type 1 diabetes (T1day), the risk of which is conferred by over 60 loci. We also describe the Type 1 Diabetes Systems Genetics website and provide a guide for its use and application to other diseases.",
keywords = "Cis-regulatory genes, Nonsynonymous genetic modifi ers, Trans-regulatory genes, Use case Type 1 diabetes, Variants that affect gene expression",
author = "Ramesh Ram and Grant Morahan",
year = "2016",
doi = "10.1007/978-1-4939-6427-7_29",
language = "English",
isbn = "9781493964253",
volume = "1488",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "597--606",
editor = "Schughart, {Klaus } and Williams, {Robert W. }",
booktitle = "Systems Genetics",
address = "United States",
}