Using systems genetics to understanding the etiology of complex disease

Ramesh Ram, Grant Morahan

Research output: Chapter in Book/Conference paperChapterpeer-review

3 Citations (Scopus)


Here, we discuss Systems Genetics applications for systematic evaluation of candidate causal genes together with follow-up bioinformatics pathway analysis. The aim of this chapter is to illustrate analytic procedures and we provide examples in the context of Type 1 diabetes (T1day), the risk of which is conferred by over 60 loci. We also describe the Type 1 Diabetes Systems Genetics website and provide a guide for its use and application to other diseases.

Original languageEnglish
Title of host publicationSystems Genetics
Subtitle of host publicationMethods and Protocols
EditorsKlaus Schughart, Robert W. Williams
PublisherHumana Press
Number of pages10
ISBN (Electronic)9781493964277
ISBN (Print)9781493964253
Publication statusPublished - 2016

Publication series

NameMethods in Molecular Biology
ISSN (Print)10643745


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