Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease

M.F. Keller; M. Saad; J. Bras; F. Bettella; N. Nicolaou; J. Simón-Sánchez; F. Mittag; F. Büchel; M. Sharma; J.R. Gibbs; C. Schulte; V. Moskvina; A. Durr; P. Holmans; L.L. Kilarski; R. Guerreiro; D.G. Hernandez; A. Brice; P. Ylikotila; H. Stefánsson; K. Majamaa; H.R. Morris; N. Williams; T. Gasser; P. Heutink; N.W. Wood; J. Hardy; M. Martinez; A.B. Singleton; M.A. Nalls; V. Plagnol; U.-M. Sheerin; S. Lesage; S. Sveinbjörnsdóttir; S. Arepalli; R. Barker; Y. Ben-Shlomo; H.W. Berendse; D. Berg; K. Bhatia; R.M.A. De Bie; A. Biffi; B. Bloem; Z. Bochdanovits; M. Bonin; K. Brockmann; J. Brooks; D.J. Burn; G. Charlesworth; H. Chen; P.F. Chinnery; S. Chong; C.E. Clarke; M.R. Cookson; J.M. Cooper; J.C. Corvol; C. Counsell; P. Damier; J.-F. Dartigues; P. Deloukas; G. Deuschl; D.T. Dexter; K.D. Van Dijk; A. Dillman; F. Durif; A. Dürr; S. Edkins; J.R. Evans; T. Foltynie; J. Gao; M. Gardner; A. Goate; E. Gray; Ó. Gústafsson; C. Harris; J.J. Van Hilten; A. Hofman; A. Hollenbeck; J. Holton; M. Hu; X. Huang; H. Huber; G. Hudson; S.E. Hunt; J. Huttenlocher; T. Illig; P.V. Jónsson; J.-C. Lambert; C. Langford; A. Lees; P. Lichtner; P. Limousin; G. Lopez; D. Lorenz; A. Mcneill; C. Moorby; M. Moore; K.E. Morrison; E. Mudanohwo; S.S. O'Sullivan; J. Pearson; J.S. Perlmutter; H. Pétursson; P. Pollak; B. Post; S.C. Potter; B. Ravina; T. Revesz; O. Riess; F. Rivadeneira; P. Rizzu; M. Ryten; S.J. Sawcer; A. Schapira; H. Scheffer; K. Shaw; I. Shoulson; E. Sidransky; C. Smith; C.C.A. Spencer; S. Steinberg; J.D. Stockton; A. Strange; K. Talbot; C.M. Tanner; A. Tashakkori-Ghanbaria; F. Tison; D. Trabzuni; B.J. Traynor; A.G. Uitterlinden; D. Velseboer; M. Vidailhet; R. Walker; B. Van De Warrenburg; M. Wickremaratchi; C.H. Williams-Gray; S. Winder-Rhodes; K. Stefánsson; P. Donnelly; I. Barroso; Jenefer Blackwell; E. Bramon; M.A. Brown; J.P. Casas; A. Corvin; A. Duncanson; J. Jankowski; H.S. Markus; C.G. Mathew; C.N.A. Palmer; R. Plomin; A. Rautanen; R.C. Trembath; A.C. Viswanathan; G. Band; C. Bellenguez; C. Freeman; G. Hellenthal; E. Giannoulatou; M. Pirinen; R. Pearson; Z. Su; D. Vukcevic; R. Gwilliam; H. Blackburn; S.J. Bumpstead; S. Dronov; M. Gillman; N. Hammond; A. Jayakumar; O.T. Mccann; J. Liddle; R. Ravindrarajah; M. Ricketts; M. Waller; P. Weston; S. Widaa; P. Whittaker; M.I. Mccarthy

doi:10.1093/hmg/dds335

Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease

M.F. Keller, M. Saad, J. Bras, F. Bettella, N. Nicolaou, J. Simón-Sánchez, F. Mittag, F. Büchel, M. Sharma, J.R. Gibbs, C. Schulte, V. Moskvina, A. Durr, P. Holmans, L.L. Kilarski, R. Guerreiro, D.G. Hernandez, A. Brice, P. Ylikotila, H. StefánssonK. Majamaa, H.R. Morris, N. Williams, T. Gasser, P. Heutink, N.W. Wood, J. Hardy, M. Martinez, A.B. Singleton, M.A. Nalls, V. Plagnol, U.-M. Sheerin, S. Lesage, S. Sveinbjörnsdóttir, S. Arepalli, R. Barker, Y. Ben-Shlomo, H.W. Berendse, D. Berg, K. Bhatia, R.M.A. De Bie, A. Biffi, B. Bloem, Z. Bochdanovits, M. Bonin, K. Brockmann, J. Brooks, D.J. Burn, G. Charlesworth, H. Chen, P.F. Chinnery, S. Chong, C.E. Clarke, M.R. Cookson, J.M. Cooper, J.C. Corvol, C. Counsell, P. Damier, J.-F. Dartigues, P. Deloukas, G. Deuschl, D.T. Dexter, K.D. Van Dijk, A. Dillman, F. Durif, A. Dürr, S. Edkins, J.R. Evans, T. Foltynie, J. Gao, M. Gardner, A. Goate, E. Gray, Ó. Gústafsson, C. Harris, J.J. Van Hilten, A. Hofman, A. Hollenbeck, J. Holton, M. Hu, X. Huang, H. Huber, G. Hudson, S.E. Hunt, J. Huttenlocher, T. Illig, P.V. Jónsson, J.-C. Lambert, C. Langford, A. Lees, P. Lichtner, P. Limousin, G. Lopez, D. Lorenz, A. Mcneill, C. Moorby, M. Moore, K.E. Morrison, E. Mudanohwo, S.S. O'Sullivan, J. Pearson, J.S. Perlmutter, H. Pétursson, P. Pollak, B. Post, S.C. Potter, B. Ravina, T. Revesz, O. Riess, F. Rivadeneira, P. Rizzu, M. Ryten, S.J. Sawcer, A. Schapira, H. Scheffer, K. Shaw, I. Shoulson, E. Sidransky, C. Smith, C.C.A. Spencer, S. Steinberg, J.D. Stockton, A. Strange, K. Talbot, C.M. Tanner, A. Tashakkori-Ghanbaria, F. Tison, D. Trabzuni, B.J. Traynor, A.G. Uitterlinden, D. Velseboer, M. Vidailhet, R. Walker, B. Van De Warrenburg, M. Wickremaratchi, C.H. Williams-Gray, S. Winder-Rhodes, K. Stefánsson, P. Donnelly, I. Barroso, Jenefer Blackwell, E. Bramon, M.A. Brown, J.P. Casas, A. Corvin, A. Duncanson, J. Jankowski, H.S. Markus, C.G. Mathew, C.N.A. Palmer, R. Plomin, A. Rautanen, R.C. Trembath, A.C. Viswanathan, G. Band, C. Bellenguez, C. Freeman, G. Hellenthal, E. Giannoulatou, M. Pirinen, R. Pearson, Z. Su, D. Vukcevic, R. Gwilliam, H. Blackburn, S.J. Bumpstead, S. Dronov, M. Gillman, N. Hammond, A. Jayakumar, O.T. Mccann, J. Liddle, R. Ravindrarajah, M. Ricketts, M. Waller, P. Weston, S. Widaa, P. Whittaker, M.I. Mccarthy

UWA Centre for Child Health Research (affiliated with the The Kids Research Institute Australia)

Research output: Contribution to journal › Article › peer-review

156 Citations (Scopus)

Original language	English
Pages (from-to)	4996-5009
Journal	Human Molecular Genetics
Volume	21
Issue number	22
DOIs	https://doi.org/10.1093/hmg/dds335
Publication status	Published - 2012

Access to Document

10.1093/hmg/dds335

Cite this

Keller, M. F., Saad, M., Bras, J., Bettella, F., Nicolaou, N., Simón-Sánchez, J., Mittag, F., Büchel, F., Sharma, M., Gibbs, J. R., Schulte, C., Moskvina, V., Durr, A., Holmans, P., Kilarski, L. L., Guerreiro, R., Hernandez, D. G., Brice, A., Ylikotila, P., ... Mccarthy, M. I. (2012). Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Human Molecular Genetics, 21(22), 4996-5009. https://doi.org/10.1093/hmg/dds335

@article{3f3e6c34beff4889a63f3eb39ce36fbe,

title = "Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease",

author = "M.F. Keller and M. Saad and J. Bras and F. Bettella and N. Nicolaou and J. Sim{\'o}n-S{\'a}nchez and F. Mittag and F. B{\"u}chel and M. Sharma and J.R. Gibbs and C. Schulte and V. Moskvina and A. Durr and P. Holmans and L.L. Kilarski and R. Guerreiro and D.G. Hernandez and A. Brice and P. Ylikotila and H. Stef{\'a}nsson and K. Majamaa and H.R. Morris and N. Williams and T. Gasser and P. Heutink and N.W. Wood and J. Hardy and M. Martinez and A.B. Singleton and M.A. Nalls and V. Plagnol and U.-M. Sheerin and S. Lesage and S. Sveinbj{\"o}rnsd{\'o}ttir and S. Arepalli and R. Barker and Y. Ben-Shlomo and H.W. Berendse and D. Berg and K. Bhatia and {De Bie}, R.M.A. and A. Biffi and B. Bloem and Z. Bochdanovits and M. Bonin and K. Brockmann and J. Brooks and D.J. Burn and G. Charlesworth and H. Chen and P.F. Chinnery and S. Chong and C.E. Clarke and M.R. Cookson and J.M. Cooper and J.C. Corvol and C. Counsell and P. Damier and J.-F. Dartigues and P. Deloukas and G. Deuschl and D.T. Dexter and {Van Dijk}, K.D. and A. Dillman and F. Durif and A. D{\"u}rr and S. Edkins and J.R. Evans and T. Foltynie and J. Gao and M. Gardner and A. Goate and E. Gray and {\'O}. G{\'u}stafsson and C. Harris and {Van Hilten}, J.J. and A. Hofman and A. Hollenbeck and J. Holton and M. Hu and X. Huang and H. Huber and G. Hudson and S.E. Hunt and J. Huttenlocher and T. Illig and P.V. J{\'o}nsson and J.-C. Lambert and C. Langford and A. Lees and P. Lichtner and P. Limousin and G. Lopez and D. Lorenz and A. Mcneill and C. Moorby and M. Moore and K.E. Morrison and E. Mudanohwo and S.S. O'Sullivan and J. Pearson and J.S. Perlmutter and H. P{\'e}tursson and P. Pollak and B. Post and S.C. Potter and B. Ravina and T. Revesz and O. Riess and F. Rivadeneira and P. Rizzu and M. Ryten and S.J. Sawcer and A. Schapira and H. Scheffer and K. Shaw and I. Shoulson and E. Sidransky and C. Smith and C.C.A. Spencer and S. Steinberg and J.D. Stockton and A. Strange and K. Talbot and C.M. Tanner and A. Tashakkori-Ghanbaria and F. Tison and D. Trabzuni and B.J. Traynor and A.G. Uitterlinden and D. Velseboer and M. Vidailhet and R. Walker and {Van De Warrenburg}, B. and M. Wickremaratchi and C.H. Williams-Gray and S. Winder-Rhodes and K. Stef{\'a}nsson and P. Donnelly and I. Barroso and Jenefer Blackwell and E. Bramon and M.A. Brown and J.P. Casas and A. Corvin and A. Duncanson and J. Jankowski and H.S. Markus and C.G. Mathew and C.N.A. Palmer and R. Plomin and A. Rautanen and R.C. Trembath and A.C. Viswanathan and G. Band and C. Bellenguez and C. Freeman and G. Hellenthal and E. Giannoulatou and M. Pirinen and R. Pearson and Z. Su and D. Vukcevic and R. Gwilliam and H. Blackburn and S.J. Bumpstead and S. Dronov and M. Gillman and N. Hammond and A. Jayakumar and O.T. Mccann and J. Liddle and R. Ravindrarajah and M. Ricketts and M. Waller and P. Weston and S. Widaa and P. Whittaker and M.I. Mccarthy",

year = "2012",

doi = "10.1093/hmg/dds335",

language = "English",

volume = "21",

pages = "4996--5009",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "22",

}

Keller, MF, Saad, M, Bras, J, Bettella, F, Nicolaou, N, Simón-Sánchez, J, Mittag, F, Büchel, F, Sharma, M, Gibbs, JR, Schulte, C, Moskvina, V, Durr, A, Holmans, P, Kilarski, LL, Guerreiro, R, Hernandez, DG, Brice, A, Ylikotila, P, Stefánsson, H, Majamaa, K, Morris, HR, Williams, N, Gasser, T, Heutink, P, Wood, NW, Hardy, J, Martinez, M, Singleton, AB, Nalls, MA, Plagnol, V, Sheerin, U-M, Lesage, S, Sveinbjörnsdóttir, S, Arepalli, S, Barker, R, Ben-Shlomo, Y, Berendse, HW, Berg, D, Bhatia, K, De Bie, RMA, Biffi, A, Bloem, B, Bochdanovits, Z, Bonin, M, Brockmann, K, Brooks, J, Burn, DJ, Charlesworth, G, Chen, H, Chinnery, PF, Chong, S, Clarke, CE, Cookson, MR, Cooper, JM, Corvol, JC, Counsell, C, Damier, P, Dartigues, J-F, Deloukas, P, Deuschl, G, Dexter, DT, Van Dijk, KD, Dillman, A, Durif, F, Dürr, A, Edkins, S, Evans, JR, Foltynie, T, Gao, J, Gardner, M, Goate, A, Gray, E, Gústafsson, Ó, Harris, C, Van Hilten, JJ, Hofman, A, Hollenbeck, A, Holton, J, Hu, M, Huang, X, Huber, H, Hudson, G, Hunt, SE, Huttenlocher, J, Illig, T, Jónsson, PV, Lambert, J-C, Langford, C, Lees, A, Lichtner, P, Limousin, P, Lopez, G, Lorenz, D, Mcneill, A, Moorby, C, Moore, M, Morrison, KE, Mudanohwo, E, O'Sullivan, SS, Pearson, J, Perlmutter, JS, Pétursson, H, Pollak, P, Post, B, Potter, SC, Ravina, B, Revesz, T, Riess, O, Rivadeneira, F, Rizzu, P, Ryten, M, Sawcer, SJ, Schapira, A, Scheffer, H, Shaw, K, Shoulson, I, Sidransky, E, Smith, C, Spencer, CCA, Steinberg, S, Stockton, JD, Strange, A, Talbot, K, Tanner, CM, Tashakkori-Ghanbaria, A, Tison, F, Trabzuni, D, Traynor, BJ, Uitterlinden, AG, Velseboer, D, Vidailhet, M, Walker, R, Van De Warrenburg, B, Wickremaratchi, M, Williams-Gray, CH, Winder-Rhodes, S, Stefánsson, K, Donnelly, P, Barroso, I, Blackwell, J, Bramon, E, Brown, MA, Casas, JP, Corvin, A, Duncanson, A, Jankowski, J, Markus, HS, Mathew, CG, Palmer, CNA, Plomin, R, Rautanen, A, Trembath, RC, Viswanathan, AC, Band, G, Bellenguez, C, Freeman, C, Hellenthal, G, Giannoulatou, E, Pirinen, M, Pearson, R, Su, Z, Vukcevic, D, Gwilliam, R, Blackburn, H, Bumpstead, SJ, Dronov, S, Gillman, M, Hammond, N, Jayakumar, A, Mccann, OT, Liddle, J, Ravindrarajah, R, Ricketts, M, Waller, M, Weston, P, Widaa, S, Whittaker, P & Mccarthy, MI 2012, 'Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease', Human Molecular Genetics, vol. 21, no. 22, pp. 4996-5009. https://doi.org/10.1093/hmg/dds335

TY - JOUR

T1 - Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease

AU - Keller, M.F.

AU - Saad, M.

AU - Bras, J.

AU - Bettella, F.

AU - Nicolaou, N.

AU - Simón-Sánchez, J.

AU - Mittag, F.

AU - Büchel, F.

AU - Sharma, M.

AU - Gibbs, J.R.

AU - Schulte, C.

AU - Moskvina, V.

AU - Durr, A.

AU - Holmans, P.

AU - Kilarski, L.L.

AU - Guerreiro, R.

AU - Hernandez, D.G.

AU - Brice, A.

AU - Ylikotila, P.

AU - Stefánsson, H.

AU - Majamaa, K.

AU - Morris, H.R.

AU - Williams, N.

AU - Gasser, T.

AU - Heutink, P.

AU - Wood, N.W.

AU - Hardy, J.

AU - Martinez, M.

AU - Singleton, A.B.

AU - Nalls, M.A.

AU - Plagnol, V.

AU - Sheerin, U.-M.

AU - Lesage, S.

AU - Sveinbjörnsdóttir, S.

AU - Arepalli, S.

AU - Barker, R.

AU - Ben-Shlomo, Y.

AU - Berendse, H.W.

AU - Berg, D.

AU - Bhatia, K.

AU - De Bie, R.M.A.

AU - Biffi, A.

AU - Bloem, B.

AU - Bochdanovits, Z.

AU - Bonin, M.

AU - Brockmann, K.

AU - Brooks, J.

AU - Burn, D.J.

AU - Charlesworth, G.

AU - Chen, H.

AU - Chinnery, P.F.

AU - Chong, S.

AU - Clarke, C.E.

AU - Cookson, M.R.

AU - Cooper, J.M.

AU - Corvol, J.C.

AU - Counsell, C.

AU - Damier, P.

AU - Dartigues, J.-F.

AU - Deloukas, P.

AU - Deuschl, G.

AU - Dexter, D.T.

AU - Van Dijk, K.D.

AU - Dillman, A.

AU - Durif, F.

AU - Dürr, A.

AU - Edkins, S.

AU - Evans, J.R.

AU - Foltynie, T.

AU - Gao, J.

AU - Gardner, M.

AU - Goate, A.

AU - Gray, E.

AU - Gústafsson, Ó.

AU - Harris, C.

AU - Van Hilten, J.J.

AU - Hofman, A.

AU - Hollenbeck, A.

AU - Holton, J.

AU - Hu, M.

AU - Huang, X.

AU - Huber, H.

AU - Hudson, G.

AU - Hunt, S.E.

AU - Huttenlocher, J.

AU - Illig, T.

AU - Jónsson, P.V.

AU - Lambert, J.-C.

AU - Langford, C.

AU - Lees, A.

AU - Lichtner, P.

AU - Limousin, P.

AU - Lopez, G.

AU - Lorenz, D.

AU - Mcneill, A.

AU - Moorby, C.

AU - Moore, M.

AU - Morrison, K.E.

AU - Mudanohwo, E.

AU - O'Sullivan, S.S.

AU - Pearson, J.

AU - Perlmutter, J.S.

AU - Pétursson, H.

AU - Pollak, P.

AU - Post, B.

AU - Potter, S.C.

AU - Ravina, B.

AU - Revesz, T.

AU - Riess, O.

AU - Rivadeneira, F.

AU - Rizzu, P.

AU - Ryten, M.

AU - Sawcer, S.J.

AU - Schapira, A.

AU - Scheffer, H.

AU - Shaw, K.

AU - Shoulson, I.

AU - Sidransky, E.

AU - Smith, C.

AU - Spencer, C.C.A.

AU - Steinberg, S.

AU - Stockton, J.D.

AU - Strange, A.

AU - Talbot, K.

AU - Tanner, C.M.

AU - Tashakkori-Ghanbaria, A.

AU - Tison, F.

AU - Trabzuni, D.

AU - Traynor, B.J.

AU - Uitterlinden, A.G.

AU - Velseboer, D.

AU - Vidailhet, M.

AU - Walker, R.

AU - Van De Warrenburg, B.

AU - Wickremaratchi, M.

AU - Williams-Gray, C.H.

AU - Winder-Rhodes, S.

AU - Stefánsson, K.

AU - Donnelly, P.

AU - Barroso, I.

AU - Blackwell, Jenefer

AU - Bramon, E.

AU - Brown, M.A.

AU - Casas, J.P.

AU - Corvin, A.

AU - Duncanson, A.

AU - Jankowski, J.

AU - Markus, H.S.

AU - Mathew, C.G.

AU - Palmer, C.N.A.

AU - Plomin, R.

AU - Rautanen, A.

AU - Trembath, R.C.

AU - Viswanathan, A.C.

AU - Band, G.

AU - Bellenguez, C.

AU - Freeman, C.

AU - Hellenthal, G.

AU - Giannoulatou, E.

AU - Pirinen, M.

AU - Pearson, R.

AU - Su, Z.

AU - Vukcevic, D.

AU - Gwilliam, R.

AU - Blackburn, H.

AU - Bumpstead, S.J.

AU - Dronov, S.

AU - Gillman, M.

AU - Hammond, N.

AU - Jayakumar, A.

AU - Mccann, O.T.

AU - Liddle, J.

AU - Ravindrarajah, R.

AU - Ricketts, M.

AU - Waller, M.

AU - Weston, P.

AU - Widaa, S.

AU - Whittaker, P.

AU - Mccarthy, M.I.

PY - 2012

Y1 - 2012

U2 - 10.1093/hmg/dds335

DO - 10.1093/hmg/dds335

M3 - Article

SN - 0964-6906

VL - 21

SP - 4996

EP - 5009

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 22

ER -