Usefulness of Neutrophil/Lymphocyte Ratio As Predictor of New-Onset Atrial Fibrillation After Coronary Artery Bypass Grafting

P.H. Gibson, B.H. Cuthbertson, B.L. Croal, D. Rae, H. El-Shafei, G. Gibson, R.R. Jeffrey, K.G. Buchan, Graham Hillis

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    154 Citations (Scopus)

    Abstract

    The neutrophil/lymphocyte (N/L) ratio integrates information on the inflammatory milieu and physiologic stress. It is an emerging marker of prognosis in patients with cardiovascular disease. We investigated the relation between the N/L ratio and postoperative atrial fibrillation (AF) in patients undergoing coronary artery bypass grafting. In a prospective cohort study, 275 patients undergoing nonemergency coronary artery bypass grafting were recruited. Patients with previous atrial arrhythmia or requiring concomitant valve surgery were excluded. The N/L ratio was determined preoperatively and on postoperative day 2. The study end point was AF lasting >30 seconds. Patients who developed AF (n = 107, 39%) had had a greater preoperative N/L ratio (median 3.0 vs 2.4, p = 0.001), but no differences were found in the other white blood cell parameters or C-reactive protein. The postoperative N/L ratio was greater in patients with AF (day 2, median 9.2 vs 7.2, p 10.14 [optimal postoperative cutoff in our cohort], 2.83 per unit, p
    Original languageEnglish
    Pages (from-to)186-191
    JournalAmerican Journal of Cardiology
    Volume105
    Issue number2
    DOIs
    Publication statusPublished - 2010

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