Use of trypan blue as an aqueous tracer dye to investigate hypotony where cyclodialysis cleft is suspected

Ying J. Khoo, Aulia A.H. Abdullah, Dao Yi Yu, William H. Morgan

Research output: Contribution to journalArticle

Abstract

Importance: A new method to help diagnose suspected cyclodialysis clefts. Background: To study the use of trypan blue stained aqueous flow patterns in diagnosing causes of hypotony where cyclodialysis clefts were suspected. Design: A case series in a tertiary care centre. Participants: Ten subjects presenting with persistent hypotony and retinal changes. Methods: Trypan blue was injected into the anterior chamber. Main Outcome Measures: The pattern of dye flow in the anterior chamber was categorized. Intraocular pressure prior to surgery was recorded. Results: All seven subjects with cyclodialysis clefts had a preferential flow to the cleft region. Two hypotonous subjects post trabeculectomy had rapid (5 seconds) and extensive lymphatic staining (6 o'clock hours extent) without visible bleb formation. Conclusions and Relevance: Preferential flow of dye to the limbus is a reliable sign of cyclodialysis cleft and helps localize cleft extent. A new cause of hypotony, “lymphatic overdrain,” is identified.

Original languageEnglish
JournalClinical and Experimental Ophthalmology
DOIs
Publication statusE-pub ahead of print - 15 May 2019

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