Use of the Collaborative Cross Gene Mine Mouse Phenotype Library to Identify Novel Genes Bone Mass and Bone Architecture

Jinbo Yuan

Research output: ThesisDoctoral Thesis

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Abstract

Bone mass is genetically regulated. We have employed micro-CT to scan hindlimbs of 848 Collaborative Cross mice across 61 strains incorporating varying ages and genders, and generated data on bone mass and architectural parameters for genetic association analyses. Gene mapping identified over 20 loci and 80 genes as candidates for regulating bone mass and microarchitecture. Correlation with human populations confirmed 10 candidate genes that were also associated with human osteoporosis. This study has utilised a novel mouse library to identify potential regulators of bone mass in mice and humans.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Xu, Jiake, Supervisor
  • Morahan, Grant, Supervisor
  • Tickner, Jennifer, Supervisor
Thesis sponsors
Award date14 Dec 2017
DOIs
Publication statusUnpublished - 2017

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