Use of serum lactate levels to predict survival for patients with out-of-hospital cardiac arrest: A cohort study

Teresa A. Williams, R. Martin, Antonio Celenza, Alex Bremner, Daniel Fatovich, Joel Krause, Steven Arena, J. Finn

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

© 2016 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine. Objectives: We examined the association of serum lactate levels and early lactate clearance with survival to hospital discharge for patients suffering an out-of-hospital cardiac arrest (OHCA). Methods: A retrospective cohort analysis was performed of patients with OHCA transported by ambulance to two adult tertiary hospitals in Perth, Western Australia. Exclusion criteria were traumatic cardiac arrest, return of spontaneous circulation prior to the arrival of the ambulance, age less than 18 years and no serum lactate levels recorded. Serum lactate levels recorded for up to 48h post-arrest were obtained from the hospital clinical information system, and lactate clearance over 48h was calculated. Descriptive and logistic regression analyses were conducted. Results: There were 518 patients with lactate values, of whom 126 (24.3%) survived to hospital discharge. Survivors and non-survivors had different mean initial lactate levels (mean±SD 6.9±4.7 and 12.2±5.5mmol/L, respectively; P
Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalEMA - Emergency Medicine Australasia
Volume28
Issue number2
DOIs
Publication statusPublished - 2016

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