Use of contemporary prostate brachytherapy approaches in clinical trials

A. Haworth, Y. Sun, M. Ebert, H. Reynolds, J. Betts, D. Wraith, C. Mitchell, D. Murphy, B. Parameswaran, S. Williams

Research output: Contribution to journalConference articlepeer-review


A number of clinical trials are investigating the role of prostate focal brachytherapy as an alternative treatment to whole gland therapy, offering the opportunity for tumour dose escalation and/or reduced toxicity. Brachytherapy, either low dose rate or high dose rate, offers a treatment choice with both precision in dose delivery and opportunity for a highly conformal, non-uniform dose distribution. Whilst multiple consensus documents have published clinical guidelines for patient selection, there are insufficient data to provide clear guidelines for treatment planning approaches along with many other technical issues when practicing focal brachy-therapy. Without consensus guidelines there is the potential for a diversity of practices to develop, leading to challenges in interpreting outcome data from multiple centres. We provide a quantitative framework for prostate focal brachytherapy that incorporates a personalized, biological approach that can be used as the foundation for future prostate focal brachytherapy trials.

Original languageEnglish
Article number012010
JournalJournal of Physics: Conference Series
Issue number1
Publication statusPublished - 7 Mar 2019
EventMini-Micro and Nano Dosimetry and Innovative Technologies in Radiation Oncology, MMNDITRO 2018 - Mooloolaba, Australia
Duration: 6 Feb 201811 Feb 2018


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